Immature Hemp Leaf Extract Anticoagulant Mechanism
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Solution Overview
Problem
Current anti-coagulant and anti-platelet agents for preventing and treating thrombosis, such as heparin and aspirin, are limited by hemorrhagic side effects, gastrointestinal injury, hypersensitivity, and high costs, necessitating the development of alternative therapeutic approaches.
Innovation Solution
Administration of a composition containing an ethanol extract from immature hemp (Cannabis sativa L.) leaves, which exhibits potent anticoagulant and anti-platelet aggregation inhibition activity without causing hemolysis or thermal instability, serving as a potential alternative to conventional agents.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If conventional anti-coagulant agents (heparin, coumarin) are used to prevent thrombosis, then thrombus formation is inhibited, but hemorrhagic side effects and gastrointestinal injury occur
Solution Approach 1:
The patent extracts and utilizes specific active components from natural sources (green tea catechins, hemp leaf extracts, ginger extracts) to create alternative anti-coagulant agents that achieve thrombus prevention without the severe side effects of conventional synthetic drugs like heparin and coumarin
Solution Approach 2:
The patent employs natural, readily available plant materials (green tea, hemp leaves, ginger) as sources of anti-coagulant compounds, providing cost-effective alternatives to expensive conventional medications while maintaining therapeutic efficacy
2Reliability
If anti-platelet agents (aspirin) are administered to inhibit platelet aggregation, then thrombosis is prevented, but gastrointestinal injury and hypersensitivity occur
Solution Approach 1:
The patent extracts anti-platelet active compounds from natural sources such as green tea catechins and hemp leaf extracts, providing alternative mechanisms for platelet aggregation inhibition that avoid the gastrointestinal toxicity and hypersensitivity reactions associated with aspirin
Solution Approach 2:
The patent changes the chemical parameters by using natural plant-derived compounds with different molecular structures and mechanisms of action compared to synthetic aspirin, thereby achieving similar anti-platelet effects with improved safety profiles
3Reliability
If conventional thrombolytics are used to treat thrombosis, then clot dissolution is achieved, but hemorrhagic side effects and high cost occur
Solution Approach 1:
The patent extracts natural thrombolytic agents from plant sources, providing cost-effective alternatives to expensive conventional thrombolytics while maintaining clot dissolution efficacy and reducing hemorrhagic complications
4Object-affected harmful factors
If hemp leaf extract is used as an alternative anti-coagulant, then thrombus formation is inhibited without hemorrhagic side effects, but the extract must be processed to remove THC
Solution Approach 1:
The patent extracts desired anti-coagulant compounds from hemp leaves while specifically removing or minimizing THC content through selective extraction methods, achieving both therapeutic efficacy and safety by separating beneficial components from harmful ones
Solution Approach 2:
The patent applies different extraction conditions and methods to different parts of the hemp plant or different components within the extract, optimizing for anti-coagulant activity while minimizing or eliminating THC content through localized processing approaches
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The immature hemp leaf extract effectively inhibits thrombus formation and platelet aggregation, offering a safer and more cost-effective option for preventing and treating thrombosis-related diseases with minimal side effects.
Implementation Method 1
the immature hemp leaf extract exhibited potent anticoagulant activity by inhibiting thrombin activity and coagulation factors
Implementation Method 2
The immature hemp leaf extract exhibited potent anti-platelet aggregation inhibition activity
Data Source
AI summary
Disclosed is a method for preventing or treating thrombosis, the method comprising administering a composition containing a hemp (Cannabis sativa L.) leaf or flower extract as an active ingredient. The hemp (Cannabis sativa L.) leaf or flower extract inhibits thrombus formation-related enzymes and coagulation factors and exhibits potent antithrombotic activity through inhibitory activity against platelet aggregation which triggers blood clotting, but with no lytic activity on human erythrocytes. In addition to being stable to heat, the extract does not lose the inhibitory activity against coagulation factors and thrombus formation-related enzymes even in the acidic condition of pH 2 and the plasma environment. Therefore, the extract is expected to find applications in preventing and treating thrombosis such as ischemic stroke and hemorrhagic stroke through blood circulation improvement.