Heparinoid External-Use Composition for Low-Temperature Stability
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Solution Overview
Problem
Ascorbic acid compounds tend to precipitate under low-temperature conditions when dissolved in water with edetic acid and glycyrrhizic acid salts, leading to poor storage stability in compositions for external use.
Innovation Solution
Incorporating a heparinoid, such as chondroitin polysulfate, into the composition containing ascorbic acid, edetic acid, and glycyrrhizic acid salts, along with water, significantly suppresses precipitation and enhances storage stability.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Stability of the object's composition
If ascorbic acid compound is dissolved in water with edetic acid salt and glycyrrhizic acid salt, then the composition has good solubility and antioxidant action, but precipitation occurs under low-temperature storage condition
Solution Approach 1:
The patent introduces a specific solvent system comprising polyhydric alcohol (glycerol, propylene glycol, or butylene glycol) combined with water as an intermediary medium. This solvent system mediates between the ascorbic acid compound and the other ingredients (edetic acid salt, glycyrrhizic acid salt), preventing precipitation while maintaining solubility and stability across a wide temperature range including low-temperature storage conditions.
2Quantity of substance
If ascorbic acid compound is used in aqueous composition, then it exhibits antioxidant action, but solubility decreases when mixed with certain solvents and components
Solution Approach 1:
The patent employs a composite solvent system combining polyhydric alcohol and water in specific proportions (polyhydric alcohol: 1-50 mass%, water: 50-99 mass%). This composite material approach leverages the complementary properties of both solvents - polyhydric alcohol enhances solubility of ascorbic acid compound while water provides the aqueous base, together preventing precipitation and maintaining stability.
3Temperature
If ascorbic acid compound is stored at low temperature, then storage stability should be improved, but precipitation of white crystals occurs within 2 days
Solution Approach 1:
The patent optimizes the solvent composition parameters, specifically the ratio of polyhydric alcohol to water and the presence of specific ingredients (edetic acid salt at 0.01-1 mass%, glycyrrhizic acid salt at 0.01-1 mass%). These parameter changes in the solvent system prevent crystal nucleation and growth even at low temperatures (5°C or lower), maintaining storage stability without precipitation for extended periods.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The addition of a heparinoid improves the storage stability of ascorbic acid-containing compositions by preventing crystal formation under low-temperature conditions, maintaining the composition's integrity and effectiveness.
Implementation Method 1
incorporating a heparinoid in addition to an ascorbic acid compound, an edetic acid salt, a glycyrrhizic acid salt, and water... precipitation under a low-temperature condition is significantly suppressed
Implementation Method 2
a composition for external use, comprising the following components (A) to (E): (A) at least one member selected from the group consisting of ascorbic acid, derivatives thereof, and salts thereof; (B) an edetic acid salt; (C) a glycyrrhizic acid salt; (D) a heparinoid; and (E) water
Data Source
AI summary
A composition for external use comprising (A) an ascorbic acid compound, derivatives and salts thereof; (B) an edetic acid salt; (C) a glycyrrhizic acid salt; (D) a heparinoid; and (E) water and an ascorbic acid compound-containing composition for external use in which precipitation under low-temperature storage conditions is suppressed.