Hepatoprotective Composition Using Extraction to Reduce Side Effects
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Solution Overview
Problem
Current hepatoprotective products, particularly those based on Chinese herbal medicines, face challenges with high component complexity, safety concerns, and increased side effects as the number of components increases, limiting their scalability and effectiveness.
Innovation Solution
A hepatoprotective traditional Chinese medicine composition is developed using a combination of Fructus Ligustri Lucidi, Herba Ecliptae, Radix Paeoniae Alba, and Rhizoma Curcumae Longae, along with clam, which are extracted and formulated to provide significant hepatoprotective efficacy with fewer components, addressing the limitations of existing products.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If the number of Chinese medicine components is increased to enhance hepatoprotective efficacy, then the therapeutic effect is improved, but the side effects and medication safety risks increase
Solution Approach 1:
The patent extracts and isolates the core effective components from traditional complex Chinese medicine formulations. By identifying and using only the essential herbs (Fructus Ligustri Lucidi, Herba Ecliptae, Radix Paeoniae Alba, Rhizoma Curcumae Longae, and clam) rather than including all traditional components, the formulation achieves hepatoprotective efficacy while eliminating unnecessary substances that could cause side effects.
2Reliability
If the number of Chinese medicine components is increased to improve therapeutic effect, then the hepatoprotective function is enhanced, but the manufacturing complexity and cost increase
Solution Approach 1:
The patent simplifies the manufacturing process by extracting only the necessary five components from traditional complex formulations. This reduction in component number directly decreases manufacturing complexity, makes large-scale production more feasible, and reduces costs while preserving the essential hepatoprotective functions.
3Adaptability or versatility
If traditional complex Chinese medicine formulations are used to ensure comprehensive treatment, then the therapeutic coverage is improved, but the medication safety cannot be guaranteed
Solution Approach 1:
The patent extracts and retains only the five most essential and safe components for hepatoprotection: Fructus Ligustri Lucidi (nourishes liver and kidney), Herba Ecliptae (nourishes liver and cools blood), Radix Paeoniae Alba (nourishes blood and regulates menstruation), Rhizoma Curcumae Longae (invigorates blood circulation), and clam (detoxifies liver). This selective extraction ensures comprehensive therapeutic coverage for liver nourishment, blood regulation, and detoxification while guaranteeing medication safety through careful component selection.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The composition effectively inhibits weight loss, reduces liver injury markers, elevates albumin levels, increases antioxidant defenses, and improves pathological changes in rat models of liver injury, demonstrating its hepatoprotective effects and safety.
Implementation Method 1
oxidative stress and lipid peroxidation
Implementation Method 2
increases antioxidant defenses
Data Source
AI summary
Disclosed is a method of preparing a hepatoprotective traditional Chinese medicine composition. The composition is prepared from Fructus Ligustri Lucidi, Herba Ecliptae, Radix Paeoniae Alba, Rhizoma Curcumae Longae and clam as main raw materials.