Herb Extract Composition for Atopic Dermatitis Treatment
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Solution Overview
Problem
Current treatments for atopic dermatitis, such as steroids and anti-histamines, provide only temporary relief and can have significant side effects, including skin thinning and growth inhibition in children, necessitating a novel, natural treatment with fewer side effects.
Innovation Solution
A composition using an herb extract mixture of Sophora flavescens, Licorice (Glycyrrhiza uralensis), Lonicera japonica, Angelica gigas, Aralia continentalis, Saussurea lappa, Bangpoong (Saposhnikovia divaricata), Zizyphus jujuba, Houttuynia cordata, Forsythia koreana, Arctii Fructus, Epimedium koreanum, Ginseng, Lithospermi Radix, Sanguisorbae officinalis, Cnidium officinale, Scrophularia buergeriana, and Reynoutria elliptica, or their lactic acid bacteria fermented solution, as an active ingredient for prevention and treatment.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If steroids and anti-histamine agents are used to treat atopic dermatitis, then symptoms are temporarily relieved, but skin thinning and growth inhibition occur
Solution Approach 1:
The patent changes the chemical composition parameters by replacing synthetic steroids and anti-histamines with a natural herb extract containing multiple plant compounds. This parameter change maintains therapeutic effectiveness while eliminating the harmful side effects associated with conventional medications.
Solution Approach 2:
The invention uses a composite herb extract comprising multiple plant materials (Sophora flavescens, Licorice, Lonicera japonica, Angelica gigas, and other herbs) working synergistically. This composite natural material provides comprehensive therapeutic effects while avoiding the toxicities of single-component synthetic drugs.
2Duration of action of moving object
If conventional treatments are used, then immediate symptom relief is achieved, but long-term safety is compromised
Solution Approach 1:
The herb extract works by addressing the underlying immune dysfunction and inflammation pathways before severe damage occurs. The natural compounds modulate the immune system proactively, preventing the development of chronic skin thinning and growth inhibition that result from prolonged steroid use.
Solution Approach 2:
The patent employs naturally derived, biodegradable herb extract compounds that are metabolized and eliminated safely from the body. These natural substances provide therapeutic action without accumulating to toxic levels, ensuring long-term safety even with extended treatment duration.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The herb extract or fermented solution effectively reduces symptoms like scratching frequency, erythema, pruritus, dry skin, edema, excoriation, erosion, and lichenification, and decreases blood IgE levels, offering a safer and more effective treatment option for atopic dermatitis.
Implementation Method 1
a lactic acid bacteria fermented solution thereof as an active ingredient
Data Source
Figure 1(A)~1(B)
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AI summary
The present invention relates to a composition for preventing or treating atopic dermatitis, and more specifically to a pharmaceutical composition and a health supplement for preventing or treating atopic dermatitis, the composition and the supplement having as active ingredients extract of a galenical mixture including sophora root, licorice, lonicer aflower, Korean angelica root, Korean aralia root, saussurea root, seselos radix, zizyphus spinosi, Houttuynia cordata, forsythia fruit, lappa fruit, Epimedium koreanum Nakai, ginseng, lithospermum, oleoresin, cnidium, scorophulariae radix, and reynoutria, or lactobacillus fermentation of the galenical extract prepared by inoculating lactobacillus to the galenical extract and fermenting same. The galenical extract or the galenical extract fermentation of the present invention shows reduction in the number of scratching, a trend of decrease in clinical features of atopic symptoms such as erythema, itchiness and dry skin, edema and hematoma, erosion, and lichenification, and reduces the IgE concentration in blood, which is related to exogenous atopic dermatitis, among laboratory animal models having atopic dermatitis, and is thereby, useful for the prevention and/or treatment of atopic dermatitis.