Herbal Composition for Brain Stroke Treatment

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Solution Overview

Problem

Current treatments for brain stroke are limited by the need for early administration and high risk of adverse side effects, with existing neuroprotective agents being ineffective in addressing cerebrovascular injury and related symptoms such as brain edema and neuronal apoptosis.

Innovation Solution

A composition comprising a mixture of Chuanxiong Rhizoma, Rhei Radix et Rhizoma, Angelicae Dahuricae Radix, Scutellaria baicalensis, Coptidis Rhizoma, Gardeniae Fructus, Carica papaya, and optional additional herbs, extracted and administered to treat brain stroke, which includes steps of heating with water, filtering, and drying to create a crude extract for use in treating cerebral vascular injury.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Reliability

If conventional neuroprotective agents are administered within 3 hours after brain stroke onset, then treatment effectiveness is improved, but the number of eligible patients is limited and adverse side effects increase

Engineering Contradiction:

Improvetreatment effectivenessVSAvoidnumber of eligible patients

Core Design Contradiction:

ReliabilityVSAdaptability or versatility

Solution Approach 1:

The patent changes the temporal parameter of administration from strict 3-hour window to 24-hour window, and modifies the dosage parameter from conventional neuroprotective agents to a specific Chinese medicine composition with defined active ingredients and concentrations, thereby expanding patient eligibility while maintaining treatment effectiveness

Inventive Principle:

Principle #35Parameter changes

Solution Approach 2:

The patent introduces a Chinese medicine composition as an intermediary substance that contains multiple active ingredients (baicalin, wogonin, catalpol, etc.) working synergistically to protect cerebral vessels and reduce edema, serving as a bridge between conventional Western medicine and traditional Chinese medicine to achieve broader applicability

Inventive Principle:

Principle #24Intermediary (Mediator)

2Reliability

If conventional neuroprotective agents are administered, then treatment is provided, but adverse side effects occur

Engineering Contradiction:

Improvetreatment effectivenessVSAvoidadverse side effects

Core Design Contradiction:

ReliabilityVSObject-affected harmful factors

Solution Approach 1:

The patent uses a composite Chinese medicine composition containing multiple herbs (Chuanxiong, Rhei Radix, Angelicae Dahuricae, Scutellaria, Coptidis Rhizoma, Gardeniae Fructus, Carica papaya) that work synergistically to protect cerebral vessels and reduce edema, replacing single-agent Western neuroprotective drugs with a multi-component formulation that reduces adverse effects

Inventive Principle:

Principle #40Composite materials

Solution Approach 2:

The patent targets specific pathological features of brain stroke (cerebral edema, vascular injury, neuronal apoptosis) with specific active ingredients that have localized effects on these pathways, such as baicalin for edema reduction and catalpol for vascular protection, thereby improving safety profile

Inventive Principle:

Principle #3Local quality

3Reliability

If brain edema is present after brain stroke, then intracranial pressure increases and cerebral ischemia worsens, but conventional treatments cannot effectively address it

Engineering Contradiction:

Improvecerebral edema reductionVSAvoidintracranial pressure

Core Design Contradiction:

ReliabilityVSObject-generated harmful factors

Solution Approach 1:

The patent changes the therapeutic approach from conventional neuroprotective agents to a Chinese medicine composition with specific active ingredients known to reduce cerebral edema and intracranial pressure, thereby addressing the harmful effects of edema more effectively

Inventive Principle:

Principle #35Parameter changes

Solution Approach 2:

The patent utilizes the natural properties of Chinese medicinal herbs to convert the harmful effect of cerebral edema into a beneficial outcome, where ingredients like Rhei Radix and Scutellaria baicalensis naturally reduce edema and intracranial pressure through their pharmacological actions

Inventive Principle:

Principle #22Blessing in disguise (Convert harm into benefit)

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

The composition effectively reduces brain edema, cerebral infarction volume, and neuronal apoptosis, demonstrating therapeutic potential in treating brain stroke with minimal organ toxicity and significant improvement in cell viability.

Implementation Method 1

The composition effectively reduces brain edema, cerebral infarction volume, and neuronal apoptosis

Methodology Applied

Scientific EffectPharmacological action:

Implementation Method 2

Methodology Applied

Scientific EffectNeuroprotective effect:

Data Source

PatentUS20210023157A1Composition for treating brain stroke

Publication Date: 2021.01.28 ENLIVEN BIOTECHNOLOGY CO LTD

AI summary

The present invention provides a method for treating brain stroke, including: administering to a subject in need a composition, including: an extract of a mixture, wherein the mixture includes Chuanxiong Rhizoma, Rhei Radix et Rhizoma, Angelicae Dahuricae Radix, Scutellaria baicalensis, Coptidis Rhizoma, Gardeniae Fructus, and Carica papaya.