Synergistic Herbal Composition for AGEs Inhibition and WAT Browning

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Solution Overview

Problem

Existing supplements do not effectively inhibit excessive generation of advanced glycation end products (AGEs) and increase lean body mass and brown adipose tissue, nor convert white adipose tissue to brown adipose tissue.

Innovation Solution

A synergistic composition comprising extracts or fractions or phytochemicals derived from Moringa oleifera, Murraya koenigii, and Curcuma longa, optionally with additional excipients, is used to inhibit AGEs and promote the conversion of WAT to BAT, increasing lean body mass and brown adipose tissue.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Reliability

If existing supplements are used, then lean body mass and brown adipose tissue are maintained, but excessive generation of advanced glycation end products (AGEs) is not inhibited and white adipose tissue cannot be converted to brown adipose tissue

Engineering Contradiction:

Improveinhibition of AGEs generationVSAvoidconversion of WAT to BAT

Core Design Contradiction:

ReliabilityVSAdaptability or versatility

Solution Approach 1:

The patent combines three distinct herbal extracts (Moringa oleifera, Murraya koenigii, and Curcuma longa) into a single synergistic composition. Each extract contributes unique bioactive compounds that work together to simultaneously inhibit AGEs generation and promote WAT to BAT conversion, resolving the contradiction between these two functions that existing single-supplement approaches could not achieve.

Inventive Principle:

Principle #5Merging (Combining)

Solution Approach 2:

The invention creates a composite nutritional supplement integrating multiple herbal extracts with complementary mechanisms of action. Moringa oleifera provides antioxidants that inhibit AGEs, Murraya koenigii contributes anti-inflammatory compounds, and Curcuma longa offers curcuminoids that regulate adipose tissue metabolism. This composite formulation achieves both AGEs inhibition and WAT-BAT conversion that individual supplements cannot accomplish.

Inventive Principle:

Principle #40Composite materials

2Quantity of substance

If protein and amino acid supplements are taken to increase lean body mass, then muscle mass increases, but excessive generation of AGEs is not prevented

Engineering Contradiction:

Improvelean body massVSAvoidAGEs formation

Core Design Contradiction:

Quantity of substanceVSObject-generated harmful factors

Solution Approach 1:

The patent addresses the harmful side effect (AGEs formation) of protein supplementation by incorporating antioxidants from Moringa oleifera and Curcuma longa that specifically inhibit the Maillard reaction. These compounds convert the potentially harmful process of protein glycation into a controlled process, allowing lean body mass accumulation while preventing excessive AGEs generation through the antioxidant and anti-glycation properties of the herbal extracts.

Inventive Principle:

Principle #22Blessing in disguise (Convert harm into benefit)

Solution Approach 2:

The herbal extracts act as intermediary substances between protein intake and AGEs formation. The bioactive compounds (quercetin, curcuminoids, and other antioxidants) serve as mediators that intercept and prevent the non-enzymatic glycation reaction, allowing the beneficial effects of protein supplementation (lean body mass increase) to occur without the harmful consequences (excessive AGEs accumulation).

Inventive Principle:

Principle #24Intermediary (Mediator)

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

The composition significantly inhibits AGE formation, downregulates pro-inflammatory cytokines, and enhances UCP1 and FGF21 expression, leading to increased lean body mass and brown adipose tissue, while reducing fat mass.

Implementation Method 1

Advanced glycation end products (AGEs), also known as glycotoxins, are a diverse group of highly active oxidant compounds, formed by a non-enzymatic reaction between reducing sugars and free amino groups of proteins, lipids, or nucleic acids and this reaction is known as Maillard or browning reaction.

Methodology Applied

Scientific EffectMaillard reaction: Chemical Bonding

Implementation Method 2

These are called Brown adipocytes, which are located in dedicated depots and express constitutively high levels of thermogenic genes.

Methodology Applied

Scientific EffectThermogenesis:

Data Source

PatentEP3697427B1Compositions for improving lean body mass, brown adipose tissue and for inhibiting advanced glycation end products

Publication Date: 2025.12.10 P L THOMAS LAILA NUTRACEUTICALS INC

Figure 1
Figure 2A~2B

AI summary

Synergistic herbal compositions comprising combination of extracts, fractions or phytochemicals or mixtures thereof derived from Moringa oleifera, Murraya koenigii and Curcuma longa for increasing lean body mass and brown adipose tissue; for accelerating the conversion of the white adipose tissue (WAT) to brown adipose tissue (BAT), inhibiting excessive generation of advanced glycation end (AGE) products and disease conditions associated with increased levels of advanced glycation end (AGE) products. The invention further provides a method of increasing lean body mass and brown adipose tissue; accelerating the conversion of the white adipose tissue (WAT) to brown adipose tissue (BAT), inhibiting excessive generation of advanced glycation end (AGE) products and disease conditions associated with increased levels of advanced glycation end (AGE) products in mammals.