Herbal Composition for Wet AMD VEGF Inhibition

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Solution Overview

Problem

Current treatments for neovascular age-related macular degeneration (AMD) are costly and have potential long-term side effects, with limited options for addressing the underlying biological cause, and existing herbal compositions do not effectively inhibit vascular endothelial growth factor (VEGF) or provide synergistic effects.

Innovation Solution

An herbal composition comprising standardized extracts from Cinnamomum verum, Terminalia chebula, Acacia catechu, Silybum marianum, Curcuma longa, and Punica granatum, with specific phytochemical concentrations, which down-regulates VEGF and inhibits angiogenesis, potentially reducing the frequency and dose of existing therapies and enhancing their efficacy.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Reliability

If conventional VEGF inhibitor therapies (Ranibizumab, Bevacizumab) are used to treat wet AMD, then the progression of vascular AMD is prevented, but the treatment cost increases significantly and long-term side effects may occur

Engineering Contradiction:

Improveeffectiveness in preventing progression of vascular AMDVSAvoidlong-term side effects and high treatment cost

Core Design Contradiction:

ReliabilityVSObject-affected harmful factors

Solution Approach 1:

The patent employs a combination of herbal extracts (Terminalia chebula, Curcuma longa, Cinnamomum verum, Acacia catechu, Punica granatum) that are naturally occurring, cost-effective alternatives to expensive monoclonal antibodies. These plant-based compounds provide sustained therapeutic effect through regular administration of affordable herbal preparations, reducing both economic burden and potential accumulation-related side effects

Inventive Principle:

Principle #27Cheap short-living objects (Disposable)

Solution Approach 2:

The patent utilizes a composite herbal formulation combining multiple plant extracts with complementary mechanisms of action. Terminalia chebula provides chebulagic acid for VEGF inhibition, Curcuma longa contributes curcumin for anti-inflammatory effects, Cinnamomum verum adds procyanidins for antioxidant protection, Acacia catechu provides catechin for angiogenesis inhibition, and Punica granatum contributes ellagic acid for synergistic anti-VEGF activity. This multi-component composite approach addresses the limitations of single-agent therapies

Inventive Principle:

Principle #40Composite materials

2Adaptability or versatility

If existing herbal compositions are used for AMD treatment, then natural therapeutic options are provided, but they do not demonstrate effective inhibitory activity against VEGF or synergistic effects

Engineering Contradiction:

Improvenatural therapeutic optionVSAvoidinhibitory activity against VEGF and synergistic effect

Core Design Contradiction:

Adaptability or versatilityVSReliability

Solution Approach 1:

The patent merges five distinct herbal extracts into a unified formulation where each component contributes specific bioactive compounds. The combination synergistically enhances VEGF inhibition through multiple mechanisms: chebulagic acid directly binds VEGF, curcumin modulates VEGF signaling pathways, procyanidins and catechin inhibit angiogenesis, and ellagic acid potentiates the overall effect. This integrated approach transforms individual herbal remedies into a coordinated therapeutic system with proven synergistic activity

Inventive Principle:

Principle #5Merging (Combining)

Solution Approach 2:

The patent optimizes the concentration parameters of each herbal extract to achieve maximum therapeutic effect. Specific ratios of Terminalia chebula, Curcuma longa, Cinnamomum verum, Acacia catechu, and Punica granatum extracts are standardized to ensure consistent delivery of bioactive compounds. This parameter optimization transforms variable herbal preparations into a reliable formulation with reproducible VEGF inhibitory activity and synergistic effects

Inventive Principle:

Principle #35Parameter changes

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

The herbal composition effectively down-regulates VEGF, inhibits angiogenesis, and enhances the therapeutic efficacy of existing treatments for neovascular AMD, offering a safer and more cost-effective alternative with higher bioavailability.

Implementation Method 1

The herbal composition effectively down-regulates VEGF, inhibits angiogenesis

Methodology Applied

Scientific EffectVEGF down-regulation:

Implementation Method 2

inhibits angiogenesis

Methodology Applied

Scientific EffectAnti-angiogenesis:

Implementation Method 3

higher bioavailability

Methodology Applied

Scientific EffectAbsorption: Absorption (physical)

Data Source

PatentEP3341002B1Herbal composition for the treatment of age related macular diseases

Publication Date: 2023.10.04 PARACHUR VIVEK ANAND

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AI summary

: The present invention discloses an herbal anti-AMD composition for treatment of age related macular diseases (AMD). More specifically, the present invention relates to an herbal composition for the prevention, management and treatment of neo-vascular or wet AMD.