Herbal Medicine Composition for Dengue Treatment
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Solution Overview
Problem
Current treatments for dengue are inadequate in addressing the severe pathophysiologic conditions such as viral multiplication, increased vascular permeability, and reduced platelet count, with no definitive drug treatment available.
Innovation Solution
A herbal medicine composition is developed using dried and finely powdered leaves of Lagerstroemia speciosa, aerial parts of Euphorbia hirta, and rhizome of Zingiber officinale, combined in a fixed-dose formulation to target viral multiplication, vascular permeability, and platelet count.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If conventional treatments are used for dengue, then general symptomatic relief is provided, but severe pathophysiologic conditions (viral multiplication, vascular permeability, platelet count) are not effectively addressed
Solution Approach 1:
The patent combines three distinct herbal extracts (Lagerstroemia speciosa, Euphorbia hirta, and Zingiber officinale) into a single fixed-dose composition, where each component targets a specific pathophysiologic aspect: L. speciosa for viral multiplication, E. hirta for platelet count elevation, and Z. officinale for vascular permeability reduction. This merging of multiple functional components into one formulation resolves the contradiction by providing comprehensive treatment coverage while maintaining a unified product structure.
Solution Approach 2:
The herbal composition is designed with multi-functionality to address three critical pathophysiologic conditions simultaneously: antiviral activity against dengue virus, elevation of platelet count in thrombocytopenic patients, and reduction of vascular permeability. This universal approach allows a single treatment to adapt to multiple disease manifestations, resolving the limitation of conventional single-function treatments.
2Reliability
If a fixed-dose combination of multiple herbal extracts is used, then comprehensive treatment coverage is achieved, but formulation complexity increases
Solution Approach 1:
The patent merges three separate herbal extracts into a single fixed-dose combination formulation with standardized ratios. This merging approach achieves comprehensive treatment coverage by incorporating multiple active components while simplifying the patient regimen to a single dosage form, thereby resolving the formulation complexity issue through unified product design.
Solution Approach 2:
The patent establishes specific parameter standards for the fixed-dose combination, including defined ratios of herbal extracts, standardized extraction methods, and controlled dosage parameters. By setting precise parameters for composition and preparation, the patent manages formulation complexity through quantifiable standards while maintaining comprehensive treatment coverage.
Data Source
AI summary
This invention relates to herbal medicine compositions for the treatment of dengue and their production. The herbal medicine compositions consist of dried and finely powdered leaves of Lagerstroemia speciosa; dried and finely powdered aerial parts of Euphorbia hirta; dried and finely powdered rhizome of Zingiber officinale; and a fixed-dose combination of all three. In another version of the formulation, the spray-dried aqueous, ethanolic, methanolic or hydroalcoholic extract of the mentioned plants were used instead.