Herbal Polysaccharide EV Complex for Optic Nerve Protection and Repair
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Solution Overview
Problem
Current vision health supplements primarily focus on optic nerve protection through food products and repair through medical means, lacking comprehensive solutions for both optic nerve protection and repair.
Innovation Solution
A herbal polysaccharide extracellular vesicle complex produced via microbial fermentation, containing polysaccharides and β-nicotinamide mononucleotide (β-NMN), which serves as carriers for neuroprotective and neuroregenerative functions.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If vision health supplements focus on phytochemicals for optic nerve protection, then antioxidant capacity is improved, but neuroregenerative function is insufficient
Solution Approach 1:
The patent combines polysaccharides (for protection) and β-NMN (for regeneration) into a single extracellular vesicle complex, enabling simultaneous optic nerve protection and neuroregeneration that cannot be achieved with separate supplements
Solution Approach 2:
The extracellular vesicle complex serves multiple functions: it provides antioxidant protection through polysaccharides while simultaneously delivering neuroregenerative effects through β-NMN, making a single supplement effective for both protection and repair
2Adaptability or versatility
If medical means are used for optic nerve repair, then neuroregenerative function is improved, but accessibility and comprehensive vision health maintenance are limited
Solution Approach 1:
The patent develops a food-based supplement using extracellular vesicles from fermented herbs, providing an affordable and accessible alternative to expensive medical interventions like stem cell therapy or growth factors
Solution Approach 2:
The patent transforms medical-grade repair materials into a food supplement format by using extracellular vesicles as carriers, changing the delivery parameter from injectable/pharmaceutical to oral supplementation for broader accessibility
3Quantity of substance
If polysaccharide-rich herbs are fermented to produce extracellular vesicles, then bioavailability and absorption are improved, but manufacturing complexity is increased
Solution Approach 1:
The fermentation process naturally generates extracellular vesicles as a byproduct, eliminating the need for separate extraction and purification steps. The vesicles self-assemble during fermentation, simplifying the overall manufacturing process while maintaining high bioavailability
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The complex enhances optic nerve protection and repair by promoting retinal thickness maintenance and ganglion cell repair, while increasing antioxidant capacity and reducing oxidative stress.
Implementation Method 1
Through microbial fermentation techniques, polysaccharide-rich herbal plants such as Dendrobium, Pouteria caimito, and goji berries (Lycium chinense) are used to generate a herbal polysaccharide extracellular vesicle (EV) complex from the fermentation broth
Data Source
AI summary
A herbal polysaccharide extracellular vesicle complex produced through fermentation, along with its preparation method and application for promoting neural repair and protecting the optic nerve. The herbal polysaccharide extracellular vesicle complex described herein can maintain retinal thickness, thereby preventing the progression of retinal damage caused by diabetes. This complex offers both optic nerve protection and enhanced neural repair.