Herbal Extract Composite for Blood Lipid Reduction
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Solution Overview
Problem
Conventional herbal medications and food products for lowering blood lipid levels are often insufficient due to low concentrations of active substances, and their components may interfere with each other's efficacy, making it necessary to develop a composite of herbal extracts that can effectively synergize to reduce cardiovascular disease incidence.
Innovation Solution
A composite of herbal extracts comprising Eucheuma okamurai Yamada, Acanthopanax senticosus, and Dioscorea alata in specific weight ratios, extracted using a solvent and processed through decoction and condensation, is formulated to create a medication that synergistically lowers total cholesterol, triglycerides, and low-density lipoprotein cholesterol, reducing fat accumulation and cardiovascular disease risk.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Quantity of substance
If conventional herbal medications or food products are used to lower blood lipid, then they provide some lipid-lowering effect, but the active substance concentration is too low to achieve significant results
Solution Approach 1:
The patent extracts active substances from three herbal sources (Eucheuma okamurai, Acanthopanax senticosus, and Dioscorea alata) to create concentrated extracts. This extraction process removes the inactive bulk material and concentrates the lipid-lowering active components, directly resolving the contradiction between low active substance concentration and insufficient efficacy.
Solution Approach 2:
The patent combines three different herbal extracts in specific weight ratios (Eucheuma okamurai extract: Acanthopanax senticosus extract: Dioscorea alata extract = 33.4%-77.7%: 11.14%-33.3%: 11.14%-33.3%) to create a composite preparation. This merging of multiple herbal sources with complementary active substances synergistically enhances the overall lipid-lowering efficacy while maintaining adequate concentration levels.
2Reliability
If multiple herbal extracts are combined to increase active substance content, then the lipid-lowering effect is enhanced, but the components may interfere with each other's efficacy
Solution Approach 1:
The patent optimizes the weight ratios of the three herbal extracts through systematic parameter adjustment. By determining the specific concentration ranges (Eucheuma okamurai extract: 33.4%-77.7%, Acanthopanax senticosus extract: 11.14%-33.3%, Dioscorea alata extract: 11.14%-33.3%), the patent achieves synergistic effects while avoiding component interference, thus resolving the contradiction between enhanced efficacy and component compatibility.
3Quantity of substance
If herbal extracts are processed to concentrate active substances, then the lipid-lowering ability is improved, but the processing complexity increases
Solution Approach 1:
The patent divides the processing into separate extraction steps for each herbal source (Eucheuma okamurai, Acanthopanax senticosus, and Dioscorea alata), allowing each extract to be prepared independently using standardized procedures. This segmentation simplifies the overall processing complexity while maintaining high active substance concentrations in each extract before combining them in the final composite preparation.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The composite effectively reduces blood lipid levels and fat accumulation in adipocytes, demonstrated through trials with adipocyte cultures and hamster studies, showing significant reduction in cardiovascular disease risk factors when administered in appropriate dosages.
Implementation Method 1
extracting samples of Eucheuma okamurai Yamada, Acanthopanax senticosus and Dioscorea alata respectively with a solvent
Implementation Method 2
condensing the liquid extract of Eucheuma okamurai Yamada, the liquid extract of Acanthopanax senticosus and the liquid extract of Dioscorea alata respectively to obtain the extract of Eucheuma okamurai Yamada, the extract of Acanthopanax senticosus and the extract of Dioscorea alata
Data Source
AI summary
A composite of herbal extracts comprises an extract of Eucheuma okamurai Yamada in a weight ratio of 33.4%-77.7%; an extract of Acanthopanax senticosus in a weight ratio of 11.14%-33.3%; and an extract of Dioscorea alata in a weight ratio of 11.14%-33.3%. Furthermore, a medication for lowering blood lipid, comprising the said composite of herbal extracts and a pharmaceutical acceptable carrier or excipient, is also disclosed.