Anti-inflammatory Composition Using Herbal Extract Mixture
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Solution Overview
Problem
Current anti-inflammatory agents from natural sources, such as Epimedium koreanum Nakai and Polygala tenuifolia Willd, exhibit cytotoxicity and low anti-inflammatory activity when used alone, limiting their effectiveness in treating inflammatory diseases.
Innovation Solution
A combination of extracts from Epimedium koreanum Nakai, Polygala tenuifolia Willd, and Polyporus umbellatus Fries, formulated in a specific ratio, is used to enhance anti-inflammatory activity while reducing toxicity, through extraction and lyophilization processes, to create a pharmaceutical or health functional food composition.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If Epimedium koreanum Nakai and Polygala tenuifolia Willd extracts are used alone, then anti-inflammatory activity is achieved, but cytotoxicity occurs and effectiveness is limited
Solution Approach 1:
The patent combines extracts from three different natural sources (Epimedium koreanum Nakai, Polygala tenuifolia Willd, and Polyporus umbellatus Fries) into a single composition. This merging approach allows the synergistic interaction of multiple extracts to enhance anti-inflammatory activity while reducing the cytotoxic effects that occur when individual extracts are used alone.
Solution Approach 2:
The invention creates a composite anti-inflammatory composition by integrating multiple natural extracts in specific ratios. This composite material approach enables the formulation to achieve both high anti-inflammatory efficacy and reduced toxicity by leveraging the complementary properties of each extract component.
2Reliability
If higher doses of single herbal extracts are used to enhance anti-inflammatory effect, then anti-inflammatory activity increases, but toxicity increases
Solution Approach 1:
By combining multiple extracts in optimized ratios, the composition achieves enhanced anti-inflammatory effects at lower overall doses compared to using single extracts at high doses. The synergistic interaction among the extracts allows for reduced individual dosages while maintaining or improving therapeutic efficacy and reducing toxicity.
3Reliability
If conventional anti-inflammatory agents are used, then anti-inflammatory effect is achieved, but safety issues and limited usage amount occur
Solution Approach 1:
The patent utilizes natural extracts from readily available herbal sources that can be sustainably harvested and processed. These natural components provide effective anti-inflammatory activity with improved safety profiles compared to conventional agents, allowing for repeated use without accumulating toxic effects.
Solution Approach 2:
The composite formulation of multiple natural extracts creates a safer anti-inflammatory agent that leverages the inherent safety of natural compounds while achieving therapeutic efficacy through synergistic interactions, avoiding the severe safety issues associated with conventional anti-inflammatory drugs.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The combined extracts demonstrate a high inhibitory effect on nitric oxide production and suppressive effects on iNOS and COX2 expression, offering a more effective anti-inflammatory treatment with reduced cytotoxicity.
Implementation Method 1
comprising the steps of extracting Epimedium koreanum Nakai, Polygala tenuifolia Willd, and Polyporus umbellatus Fries
Implementation Method 2
concentrating the extracts, and lyophilizing the extracts
Data Source
AI summary
The present invention relates to an anti-inflammatory composition comprising Epimedium koreanum Nakai, Polygala tenuifolia Willd, and Polyporus umbellatus Fries extracts or a mixture thereof as an active ingredient. The extracts and mixture prepared according to the present invention exhibit a high inhibitory effect against nitric oxide and a suppressive effect against the expression of iNOS and COX2 and thus can be advantageously used as an anti-inflammatory composition.