Combined Herbal Extract Composition for Chronic Skin Ulcer Healing
Find Innovative SolutionsGenerate Solutions
Solution Overview
Problem
Current treatments for chronic skin ulcers, such as diabetic foot ulcers, are limited by high costs, safety concerns, and ineffective delivery of growth factors, and there is a need for more effective, low-cost, and low-side-effect treatments from natural resources.
Innovation Solution
A topical pharmaceutical composition comprising a combined herb extract of Longanae Arillus, Ligustici Tenuissimi Rhizoma, and Polygalae radix, formulated to inhibit pro-inflammatory cytokines and promote wound healing, is developed.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If conventional growth factor treatments are used, then wound healing is promoted, but treatment cost increases and safety concerns arise
Solution Approach 1:
The patent replaces expensive recombinant growth factors with a cost-effective herbal extract composition containing polygalae radix, longanae arillus, and ligustici tenuissimi rhizoma. This natural extract provides sustained therapeutic effect without the high cost and safety concerns associated with synthetic growth factors, making treatment accessible and safe for chronic wound patients
Solution Approach 2:
The herbal extract acts as an intermediary substance that mediates wound healing by modulating the inflammatory response and promoting tissue repair through natural bioactive compounds. Instead of directly applying recombinant growth factors, the patent uses this intermediate herbal composition to regulate the wound healing process, reducing direct exposure to potentially harmful synthetic substances
2Productivity
If high concentrations of growth factors are applied frequently, then wound healing is enhanced, but skin tissue permeability limitations reduce effectiveness
Solution Approach 1:
The patent changes the chemical composition parameters by using a multi-herb extract formulation with specific ratios of polygalae radix, longanae arillus, and ligustici tenuissimi rhizoma. This natural extract contains diverse bioactive compounds that work synergistically to promote wound healing, overcoming the permeability barrier that limits the effectiveness of single-component synthetic growth factors when applied at high concentrations
3Reliability
If the inflammatory stage continues, then pro-inflammatory cytokines increase, but wound healing progress is delayed
Solution Approach 1:
The herbal extract composition performs preliminary anti-action by preemptively modulating the inflammatory response through natural anti-inflammatory compounds in polygalae radix, longanae arillus, and ligustici tenuissimi rhizoma. This prevents excessive inflammation from developing and delaying wound healing, acting before the harmful effects of prolonged inflammation can occur
Solution Approach 2:
The patent converts the harmful prolonged inflammatory response into a beneficial controlled healing process. The herbal extract takes the excessive pro-inflammatory cytokine activity and transforms it into a balanced immune response that promotes tissue repair. The same inflammatory pathway that causes delay is redirected to support wound healing through the modulatory effects of the natural extract
Data Source
AI summary
The present invention is related to a topical pharmaceutical composition and cosmetic composition comprising a combined herb extract of Longanae Arillus, Ligustici Tenuissimi Rhizomaand Polygalae radix as an active ingredient to treat and alleviate skin ulcer.