Herbal Extraction for Effervescent Suppository Ovarian Therapy
Find Innovative SolutionsGenerate Solutions
Solution Overview
Problem
Existing estrogen supplements for treating ovarian diseases cause adverse symptoms and inflammation, necessitating the development of a method for an anti-inflammatory ovary-protecting herb to manage ovarian inflammation and estrogen levels effectively.
Innovation Solution
A method involving the extraction and preparation of an anti-inflammatory ovary-protecting herb comprising an external drug made from Sophora flavescens, Fructus cnidii, Phellodendron amurense, Rhizoma atractylodis, and Capillary artemisia, and an internal drug containing estradiol, sodium dodecyl sulfate, and other components, designed to minimize systemic side effects and enhance local drug concentration.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Quantity of substance
If estrogen supplements are used to treat ovarian diseases, then estrogen levels are supplemented, but adverse symptoms and inflammation occur
Solution Approach 1:
The patent divides the treatment into two separate components: an internal drug containing estradiol for systemic estrogen supplementation, and an external drug containing anti-inflammatory Chinese medicinal materials applied locally to the vaginal area. This segmentation allows each component to perform its specific function without the harmful side effects of combined systemic estrogen therapy alone.
Solution Approach 2:
The external drug acts as an intermediary substance applied locally to the vaginal mucosa, providing anti-inflammatory protection and reducing adverse effects of estrogen supplementation without requiring high systemic estrogen doses, thereby minimizing harmful side effects.
2Object-affected harmful factors
If radical treatment of ovarian diseases is performed, then inflammation is reduced, but estrogen level drops significantly
Solution Approach 1:
The treatment is segmented into internal and external components: the internal drug supplements estrogen levels after radical treatment, while the external drug with anti-inflammatory Chinese medicines addresses any residual or recurrent inflammation, allowing independent optimization of both functions.
Solution Approach 2:
The patent changes the parameter of drug administration by using both systemic (internal) and local (external) routes, allowing estrogen supplementation without proportionally increasing systemic inflammation risk, as the external application provides localized anti-inflammatory action.
3Quantity of substance
If external drug with Chinese medicinal materials is applied, then local drug concentration is increased, but preparation complexity increases
Solution Approach 1:
The Chinese medicinal materials are pre-processed through decoction and filtration to create a concentrated external drug formulation before application. This preliminary preparation ensures high local drug concentration while standardizing the process to manage complexity.
Solution Approach 2:
The patent changes the physical state of the medicinal materials from solid herbs to a liquid decoction, then to a concentrated external drug formulation, increasing bioavailability and local concentration while managing preparation steps through systematic processing.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The method provides a synergistic effect with reduced systemic side effects and increased local drug concentration, effectively managing ovarian inflammation and estrogen levels, promoting therapeutic efficacy and minimizing adverse reactions.
Implementation Method 1
a decoction method is used to prepare the external drug, which comprises the following steps: Step S1: weighing 86 g of Sophora flavescens, 182 g of Fructus cnidii, 66 g of Phellodendron amurense, 146 g of Rhizoma atractylodis and 76 g of Capillary artemisia, washing the above five medicine herbs and then placing the medicinal materials in a decoction pot, adding water above the surfaces of the medicinal materials to soak the medicinal materials for 30 min, decocting twice in total based on the decoction method, and then filtering using a filter screen to obtain filtrate
Implementation Method 2
Step S2: merging the two filtrates, performing vacuum concentration to 1000 ml, adding 3 times the amount of 95% ethanol after cooling while stirring so that the content of alcohol in the merged filtrate reaches about 70%
Implementation Method 3
recovering ethanol from the filtrate to form a solution, and then evaporating the solution until an extract is formed for later use; wherein the method for preparing the solution into the extract is as follows: (1) shaking the collected solution, then putting the solution into a beaker and heating the solution, wherein in the process of heating, the temperature is raised so that ethanol is evaporated out
Data Source
AI summary
The present disclosure relates to the technical field of herbal extraction and preparation, and particularly to a method for extraction and preparation of an anti-inflammatory ovary-protecting herb. The method comprises an internal drug and an external drug, wherein the external drug comprises 86 g of Sophora flavescens, 182 g of Fructus cnidii, 66 g of Phellodendron amurense, 146 g of Rhizoma atractylodis, 76 g of Capillary artemisia, matrix S-40, sodium dihydrogen phosphate and polysorbitol-80. The Sophora flavescens and Fructus cnidii in the external drug of the present disclosure have the functions of clearing heat and dampness, dispelling wind, killing insects and relieving itching. Through scientific extraction, the Sophora flavescens and Fructus cnidii combined with adjuvant medicinal materials such as Phellodendron amurense, Rhizoma atractylodis and Capillary artemisia are prepared into an effervescent suppository.