TCM Lipid Extracts for In Vivo Nucleic Acid Uptake and Stability
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Solution Overview
Problem
Nucleic acid molecules, particularly small RNA, face challenges in efficient delivery to target organs and cells in vivo due to degradation and short half-life, limiting their therapeutic potential.
Innovation Solution
Lipid components extracted from traditional Chinese medicines like Rhodiola crenulata, Taraxacum mongolicum, and Andrographis paniculata are used to promote the absorption and entry of nucleic acids into cells, formulated into reagents, pharmaceutical compositions, or kits for targeted delivery.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If nucleic acid molecules are used as therapeutic drugs, then they can bind to proteins and form catalytic centers, but they are easily degraded and have short half-life in vivo
Solution Approach 1:
The patent uses lipid compounds as intermediary carriers to deliver nucleic acid molecules to target cells. The lipid-nucleic acid complex protects the nucleic acid from degradation in vivo while maintaining its biological activity, resolving the contradiction between therapeutic reliability and compositional stability.
2Reliability
If nucleic acid molecules are delivered to target cells, then therapeutic effects can be achieved, but efficient delivery to target organs and cells is difficult due to degradation
Solution Approach 1:
Lipid compounds serve as intermediary delivery vehicles that facilitate the transport of nucleic acids to target cells. This intermediary system overcomes the degradation problem and enables efficient delivery, making the therapeutic effect achievable while simplifying the delivery process.
3Productivity
If lipid components from traditional Chinese medicines are used, then absorption and entry of nucleic acids into cells is promoted, but the compounds must be extracted and formulated
Solution Approach 1:
The patent extracts specific lipid components from traditional Chinese medicine materials to create nucleic acid delivery agents. This extraction process isolates the active lipid compounds that promote cellular uptake, achieving high delivery efficiency while creating a standardized formulation process.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
Enhances the delivery and biological activity of nucleic acids, such as small RNA, by stabilizing them for therapeutic effects in vivo.
Implementation Method 1
these lipids derived from the traditional Chinese medicines can promote absorption/entry of nucleic acids, such as small RNA into cells
Data Source
AI summary
The present application relates to extracting a plurality of compounds from a traditional Chinese medicine, or synthesizing a compound capable of promoting nucleic acid delivery, and utilizing the extracted compound, or a plurality of combinations to promote absorption and entry of a nucleic acid such as sRNA into a target cell, and to facilitate the entry of a nucleic acid into a target site in a subject in need thereof.