Herbal Liver-Protecting Compound Preparation with Reflux Extraction
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Solution Overview
Problem
Existing liver-protecting drugs on the market take a long time to show effects and do not effectively inhibit liver damage, increasing organ burden.
Innovation Solution
A process for preparing a liver-protecting compound ingredient comprising an internal drug and an external drug, using a combination of traditional Chinese medicinal herbs, including astragalus membranaceus, Salvia miltiorrhiza, and others, through thermal reflux extraction and decoction, followed by vacuum concentration and application on a plaster cloth.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If existing liver-protecting drugs are used to promote metabolism level, then liver-protecting effect is achieved, but the effect is slow and organ burden increases
Solution Approach 1:
The patent changes the pharmacological parameters by combining multiple herbs with different mechanisms of action (astragalus membranaceus for cell membrane protection, Salvia miltiorrhiza for lipid peroxidation inhibition, Ligustrum lucidum for fibrosis prevention) to achieve both rapid and sustained liver protection without increasing organ burden
Solution Approach 2:
The patent uses a composite formulation containing 19 different Chinese medicinal herbs working synergistically to provide comprehensive liver protection that is both rapid in onset and sustained in effect, eliminating the need to choose between speed and durability
2Reliability
If existing liver-protecting drugs are used to promote metabolism level, then liver-protecting effect is achieved, but the effect is slow and organ burden increases
Solution Approach 1:
The patent changes the pharmacological parameters by combining multiple herbs with different mechanisms of action (astragalus membranaceus for cell membrane protection, Salvia miltiorrhiza for lipid peroxidation inhibition, Ligustrum lucidum for fibrosis prevention) to achieve both rapid and sustained liver protection without increasing organ burden
Solution Approach 2:
The patent converts the potential harm of multiple drug combinations into a benefit by carefully selecting herbs that work synergistically to protect the liver without accumulating organ burden, turning what could be an excessive treatment into a balanced, sustainable therapy
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The process results in a liver-protecting compound that effectively inhibits lipid peroxidation, reduces liver cell damage, and protects against liver fibrosis, with improved efficacy and quality control.
Implementation Method 1
extracting the crude particles twice by thermal reflux extraction such as ethanol thermal reflux extraction
Implementation Method 2
adding 600 ml of ethanol into the crude particles for 3 h of reflux extraction
Implementation Method 3
placing 40 g of radix bupleuri, 40 g of Atractylodes macrocephala, 40 g of radix curcumae, 40 g of Angelica sinensis and 40 g of pericarpium citri reticulatae into a distillation vessel, adding 600 ml into the distillation vessel, and then distilling to collect distillate
Implementation Method 4
performing vacuum concentration on the solution and then taking out the solution
Data Source
AI summary
The present disclosure relates to the technical field of liver-protecting ingredient preparation processes, and particularly to a process for preparing an efficient liver-protecting compound ingredient. The process comprises an internal drug and an external drug, wherein the internal drug comprises 65 g of astragalus membranaceus, 65 g of Salvia miltiorrhiza, 50 g of Ligustrum lucidum, 50 g of the fruit of Chinese wolfberry, 50 g of Tuckahoe, 40 g of radix bupleuri, 40 g of Schisandra chinensis, 40 g of Codonopsis pilosula, 40 g of Pinellia ternata, 40 g of rhizoma dioscoreae, 40 g of radix isatidis, 40 g of Atractylodes macrocephala, 40 g of radix curcumae, 40 g of Radix Paeoniae Alba, 40 g of Hedyotis diffusa, 40 g of Angelica sinensis, 40 g of pericarpium citri reticulatae, 40 g of honeysuckle, 40 g of rhizoma polygonati, and 30 g of parched hawthorn fruit.