Herbal Composition for Menopausal Syndrome Treatment

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Solution Overview

Problem

Current treatments for menopausal syndrome, such as hormone replacement therapy, come with significant side effects, and existing animal models like ovariectomized rats have limitations, necessitating a more effective and safer therapeutic option.

Innovation Solution

A composition containing a mixed extract of cuscutae semen, Evodiae fructus, and Dipsaci radix, extracted using solvents like water or ethanol, is developed to alleviate menopausal symptoms like heart function deterioration and depression, with a preferred ratio of 20-30 wt%:10-15 wt%:20-30 wt% respectively.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Reliability

If hormone replacement therapy is used to treat menopausal symptoms, then the effectiveness in treating symptoms is improved, but the risk of serious side effects such as breast cancer, coronary artery disease, and stroke increases

Engineering Contradiction:

Improveeffectiveness in treating menopausal symptomsVSAvoidrisk of serious side effects

Core Design Contradiction:

ReliabilityVSObject-affected harmful factors

Solution Approach 1:

The patent replaces long-term hormone replacement therapy with a natural herb-based composition that can be used safely over extended periods without the cumulative risks associated with synthetic hormones. The herbal extract acts as a temporary, natural alternative that addresses menopausal symptoms without causing the serious side effects of conventional hormone therapy.

Inventive Principle:

Principle #27Cheap short-living objects (Disposable)

Solution Approach 2:

The patent uses a composite herbal composition containing multiple medicinal herbs (cuscutae semen, Evodiae fructus, and Dipsaci radix) rather than a single substance. This composite approach synergistically addresses various menopausal symptoms while minimizing side effects through the balanced interaction of different herbal components.

Inventive Principle:

Principle #40Composite materials

2Ease of manufacture

If ovariectomized animal models are used to study menopause, then the experimental setup is simplified, but the model fails to represent the natural menopausal process since 90% of menopausal women retain their ovaries

Engineering Contradiction:

Improvesimplicity of experimental setupVSAvoidrepresentativeness of menopausal process

Core Design Contradiction:

Ease of manufactureVSAdaptability or versatility

Solution Approach 1:

The patent acknowledges the limitation of OVX models but uses VCD-induced models instead, which naturally replicate the menopausal process in animals that retain their ovaries. This converts the previously harmful simplification into a beneficial natural model that accurately represents human menopause, allowing for more clinically relevant research on herbal treatments.

Inventive Principle:

Principle #22Blessing in disguise (Convert harm into benefit)

Data Source

PatentUS11690888B2Composition for preventing or treating menopausal syndrome, containing medicinal herb extract as active ingredient

Publication Date: 2023.07.04 KOREA PHARMA CO LTD

AI summary

The present invention relates to a composition for preventing or treating menopausal syndrome, containing a medicinal herb extract as an active ingredient. The composition has effects of alleviating heart function deterioration and depression, which are caused by menopause, and has biostability, thereby being usable as a composition for preventing or treating female menopausal syndrome.