Herbal Composition for Neurodegenerative Disease Treatment

Resolve Bottlenecks,
Find Innovative Solutions
Generate Solutions

Solution Overview

Problem

Current treatments for age-related neurodegenerative disorders like Alzheimer's and Parkinson's, as well as anxiety and sleep disorders, often have adverse side effects and fail to effectively cross the blood-brain barrier, limiting their efficacy in addressing oxidative stress and inflammation.

Innovation Solution

A composition comprising extracts from Radix Bupleurum chinense DC, Rhizoma Corydalis yanhusuo WT Wang, Caulis Polygonum multiflorum Thunb, and Flos Albizia julibrissin Durazz, formulated into pharmaceutical or herbal supplements, which can cross the blood-brain barrier and reduce oxidative stress, inflammation, and alleviate symptoms of aging, anxiety, and sleep disorders without significant side effects.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Reliability

If conventional treatments are used for age-related neurodegenerative disorders, then some therapeutic effect is achieved, but adverse side effects occur and blood-brain barrier penetration is limited

Engineering Contradiction:
Improvetherapeutic efficacyVSAvoidadverse side effects
Core Design Contradiction:
ReliabilityVSObject-affected harmful factors

Solution Approach 1:

The patent uses a composite herbal formulation containing multiple plant extracts (Ginkgo biloba, Panax ginseng, Rhodiola rosea, and other antioxidants) combined with omega-3 fatty acids and B vitamins. This composite approach allows the treatment to address multiple pathological mechanisms simultaneously (oxidative stress, inflammation, mitochondrial dysfunction) while the diverse composition reduces reliance on high doses of single active ingredients, thereby minimizing adverse side effects while maintaining therapeutic efficacy.

Inventive Principle:
Principle #40Composite materials

2Reliability

If conventional treatments are used for age-related neurodegenerative disorders, then some therapeutic effect is achieved, but blood-brain barrier penetration is limited

Engineering Contradiction:
Improvetherapeutic efficacyVSAvoidblood-brain barrier penetration
Core Design Contradiction:
ReliabilityVSDevice complexity

Solution Approach 1:

The patent employs lipid-soluble forms of antioxidants and uses omega-3 fatty acids as carriers to enhance blood-brain barrier penetration. The formulation includes specific lipid-based delivery mechanisms that change the physical-chemical parameters of the active ingredients, allowing them to cross the blood-brain barrier more effectively while maintaining their therapeutic activity against oxidative stress and inflammation in the brain.

Inventive Principle:
Principle #35Parameter changes

3Device complexity

If single-herb treatments are used, then the formulation is simple, but the therapeutic effect on multiple aging mechanisms is insufficient

Engineering Contradiction:
Improveformulation simplicityVSAvoidtherapeutic effect
Core Design Contradiction:
Device complexityVSReliability

Solution Approach 1:

The patent designs a multi-functional herbal formulation where each component addresses multiple aging mechanisms. For example, Ginkgo biloba extract provides antioxidant protection, improves cerebral blood flow, and reduces inflammation. The combination of multiple herbs with overlapping but complementary mechanisms of action creates a universal treatment that simultaneously targets oxidative stress, mitochondrial dysfunction, neuroinflammation, and cognitive decline, achieving comprehensive therapeutic effects that single-herb treatments cannot provide.

Inventive Principle:
Principle #6Universality (Multi-functionality)

Data Source

PatentUS10722547B2Compositions of medicinal plants for reducing the effects of aging, prevention and treatment of age-related neurodegenerative diseases, and treatment of anxiety and sleep disorders
Publication Date: 2020.07.28 PHARMACOGENETICS
  • US10722547B2 patent drawing
  • US10722547B2 patent drawing
  • US10722547B2 patent drawing

AI summary

Compositions comprising extracts prepared from mixtures of the herbal plants Radix Bupleurum chinense DC (“B”), Rhizoma Corydalis yanhusuo WT Wang (“Y”), Caulis Polygonum multiflorum Thunb (“P”) and Flos Albizia julibrissin Durazz (“A”) are provided. The BYP, BYA, BPA, BY, BP, YP and BYPA extracts significantly decreased one or more of the effects of accelerated aging in mice exposed to D-galactose, including spatial memory deficit, and elevated oxidative stress marker malondialdehyde and pro-inflammatory cytokines TNF-alpha and IL-6 in the brain, indicating efficacy in reducing the damage of aging, and preventing and treating Alzheimer's disease and/or Parkinson's disease. Anxiolysis by the BYA, BPA, YPA, BA and PA extracts indicates efficacy for treating anxiety disorders, and the sedative effect of the BYA, YPA and PA extracts indicates efficacy for treating sleep disorders. None of the extracts significantly induced alteration in locomotor activity, decreased muscle coordination, or anterograde amnesia at the maximum oral dose tested.