Herbal and Oil Composition for Lipid Metabolism Modulation

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Solution Overview

Problem

Current dietary supplements fail to effectively improve beneficial lipid metabolism and promote the incorporation of polyunsaturated lipids into biochemical pathways and biological membranes, leading to inadequate cardiovascular health and increased risk of cell proliferation diseases such as cancer.

Innovation Solution

A novel herbal and oil composition comprising rosemary extract, oregano extract, and a polyunsaturated oil, specifically fish oil, which enhances the uptake and metabolism of beneficial polyunsaturated lipids, modulating fatty acid composition and metabolism, and regulating enzymes like lipoxygenases and cyclooxygenases to improve cardiovascular health and inhibit cell proliferation.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Reliability

If conventional dietary supplements are used, then basic fatty acid supplementation is provided, but effective improvement of beneficial lipid metabolism and incorporation of polyunsaturated lipids into biochemical pathways and biological membranes does not occur

Engineering Contradiction:
Improveeffectiveness of lipid metabolism improvementVSAvoidincorporation rate of polyunsaturated lipids into membranes
Core Design Contradiction:
ReliabilityVSProductivity

Solution Approach 1:

The patent combines polyunsaturated fish oil with specific herbal extracts (rosemary, oregano, thyme, basil) to create a composite supplement formulation. This composite approach enhances the incorporation of polyunsaturated lipids into cell membranes by synergistically combining the lipid source with herbal compounds that facilitate absorption and metabolic utilization, thereby resolving the contradiction between supplement reliability and membrane incorporation productivity.

Inventive Principle:
Principle #40Composite materials

Solution Approach 2:

The invention modifies the chemical and biological parameters of the supplement by selecting specific herbal extracts with known metabolic effects. These parameter changes in the supplement composition (adding phenolic compounds, terpenes, and other bioactive molecules from herbs) enhance the body's ability to process and incorporate polyunsaturated fatty acids into membranes, thus improving both reliability and productivity of lipid metabolism.

Inventive Principle:
Principle #35Parameter changes

2Reliability

If fish oil is consumed to increase omega-3 fatty acids, then cardiovascular health benefits are achieved, but inadequate modulation of fatty acid composition and metabolism occurs

Engineering Contradiction:
Improvecardiovascular health benefitVSAvoidmodulation capability of fatty acid metabolism
Core Design Contradiction:
ReliabilityVSAdaptability or versatility

Solution Approach 1:

The patent creates a multi-functional supplement that not only provides omega-3 fatty acids for cardiovascular health but also incorporates herbal extracts that simultaneously modulate fatty acid composition, regulate lipid metabolism enzymes, and influence eicosanoid production. This universal formulation addresses multiple metabolic pathways at once, enhancing adaptability while maintaining cardiovascular benefits.

Inventive Principle:
Principle #6Universality (Multi-functionality)

Solution Approach 2:

The herbal extracts act as intermediaries that facilitate the metabolism and utilization of fish oil components. These herbal compounds mediate the interaction between dietary polyunsaturated fatty acids and metabolic pathways, enhancing the body's ability to incorporate and utilize omega-3s effectively, thereby improving modulation capability while preserving cardiovascular health benefits.

Inventive Principle:
Principle #24Intermediary (Mediator)

3Object-affected harmful factors

If the ratio of n-3 to n-6 dietary fatty acids is decreased, then inflammatory response increases, but achieving adequate n-3 incorporation into membranes is difficult

Engineering Contradiction:
Improveinflammatory response levelVSAvoidincorporation efficiency of n-3 fatty acids
Core Design Contradiction:
Object-affected harmful factorsVSProductivity

Solution Approach 1:

The patent employs herbal extracts that alter metabolic parameters to enhance n-3 fatty acid incorporation efficiency. These herbal compounds modify enzyme activity and membrane permeability parameters, facilitating greater uptake and retention of omega-3 fatty acids in cell membranes, thereby improving incorporation productivity while simultaneously reducing inflammatory responses through balanced fatty acid composition modulation.

Inventive Principle:
Principle #35Parameter changes

Data Source

PatentUS9808495B2Compositions and methods for modulating lipid composition
Publication Date: 2017.11.07 NEW CHAPTER INC
  • US9808495B2 patent drawing
  • US9808495B2 patent drawing
  • US9808495B2 patent drawing

AI summary

The present subject matter relates to a novel herbal and oil composition and methods for modulating fatty acid composition and metabolism in an animal. In one aspect, the subject matter involves a composition comprising rosemary extract, oregano extract, and a polyunsaturated oil. In a particular embodiment, the polyunsaturated oil is fish oil or a derivative thereof. In some embodiments, the present subject matter relates to methods for modulating essential dietary fatty acid composition of lipoprotein particles or cell membranes, modulating essential fatty acid metabolism, regulating the activity of lipoxygenases and cyclooxygenases, improving cardiovascular health, and/or inhibiting cell proliferation diseases and disorders.