Chinese Herbal Patch Formulation for Anti-Inflammatory Efficacy

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Solution Overview

Problem

Current Chinese herbal medicine patches, such as Panchrest plaster, contain toxic ingredients like Radix Aconiti, Momordica Cochinchinensis, and Radix Aconiti Kusnezoffii, which cause dermal irritation and toxicity, and the extraction process can lead to incomplete ingredient extraction and heavy metal residue issues.

Innovation Solution

A Chinese herbal medicine composition and extractive that replaces toxic ingredients with non-irritating alternatives, specifically using Rhizoma Bletillae, Cortex Cinnamomi, Radix Angelicae Formosanae, Radix Angelicae Sinensis, Paeonia Lactiflora, Rhizoma Notopterygii, Radix Linderae, Glycyrrhizae, Radix Angelicae Pubescentis, and Radix Et Rhizoma Rhei, along with added medicinal materials like Zingiber Officinale and Myrrha, using a specialized extraction method to enhance efficacy and safety.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Reliability

If traditional Panchrest plaster formula is used with Radix Aconiti, Momordica Cochinchinensis, and Radix Aconiti Kusnezoffii, then antiinflammation and acesodyne effects are achieved, but toxicity and dermal irritation occur

Engineering Contradiction:

Improveantiinflammation and acesodyne efficacyVSAvoiddermal irritation and toxicity

Core Design Contradiction:

ReliabilityVSObject-affected harmful factors

Solution Approach 1:

The patent removes the toxic ingredients (Radix Aconiti, Momordica Cochinchinensis, and Radix Aconiti Kusnezoffii) from the traditional Panchrest plaster formula while retaining the therapeutic effects through alternative non-toxic herbal compositions

Inventive Principle:

Principle #2Taking out (Extraction)

Solution Approach 2:

The patent converts the harmful toxic effects of traditional ingredients into beneficial therapeutic effects by selecting alternative herbs that provide similar antiinflammation and acesodyne properties without toxicity, as demonstrated by animal tests showing no skin irritation

Inventive Principle:

Principle #22Blessing in disguise (Convert harm into benefit)

2Productivity

If oleum sesami is used for extraction at high temperature, then extraction efficiency is improved, but ingredient destruction and heavy metal residue occur

Engineering Contradiction:

Improveextraction efficiencyVSAvoidingredient destruction and heavy metal residue

Core Design Contradiction:

ProductivityVSObject-generated harmful factors

Solution Approach 1:

The patent changes the extraction parameters by using ethanol as solvent and controlling extraction temperature and time, replacing the traditional high-temperature oleum sesami extraction method to prevent ingredient destruction and heavy metal contamination

Inventive Principle:

Principle #35Parameter changes

Solution Approach 2:

The patent replaces the mechanical high-temperature extraction process with a chemical extraction method using ethanol, which achieves complete extraction of active ingredients without the harmful side effects of high-temperature processing

Inventive Principle:

Principle #28Mechanics substitution (Replace mechanical system)

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

The new composition effectively addresses inflammation, detumescence, and analgesia without skin irritation, offering improved safety and efficacy compared to traditional patches, as demonstrated by animal tests and HPLC analysis, with enhanced extraction processes ensuring complete ingredient extraction and reduced heavy metal residues.

Implementation Method 1

a special extraction and preparation method

Methodology Applied

Scientific EffectExtraction: Liquid-Liquid Extraction

Implementation Method 2

making the ingredients in Chinese herbal medicine patch penetrate into the skin of body

Methodology Applied

Scientific EffectDissolution: Solvation

Implementation Method 3

HPLC analysis

Methodology Applied

Scientific EffectChromatography: Chromatography

Data Source

PatentEP2474314B1Antiphlogistic, antioncotic and analgesic chinese herbal composition preparative method and usage thereof

Publication Date: 2014.11.05 UNI PRESIDENT BIOTECH

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AI summary

A Chinese herbal medicine composition used for antiinflammation, detumescence and acesodyne, comprising first type of medicinal materials and second type of medicinal materials. The first type of medicinal materials include Rhizoma Bletillae, Cortex Cinnamomi, Radix Angelicae Formosanae, Radix Angelicae Sinensis, Paeonia Lactiflora, Rhizoma Notopterygii, Radix Linderae, Glycyrrhizae, Radix Angelicae Pubescentis, and Radix Et Rhizoma Rhei. The second type of medicinal materials is one, two or three selected from the group cosisting of Zingiber Officinale, Olibanum and Myrrha. The preparation method for the Chinese herbal medicine composition comprises the following steps: adding the first type of medicinal materials and the second type of medicinal materials into a container with organic solvent, heating, filtering, and then condensing the filtrate into an extratum.