Herbal-Pharmaceutical Composition Stability via Poloxamer and Buffering

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Solution Overview

Problem

Combining herbal extracts with pharmaceutical compositions is challenging due to compatibility issues, reactive chemical moieties, and stability concerns, leading to degradation and separation of active pharmaceuticals, which complicates the creation of stable, synergistic formulations for conditions like common cold and influenza.

Innovation Solution

A method for combining herbal extracts with pharmaceuticals involves a detailed stepwise manufacturing process, including dissolving herbal extracts, adding poloxamer, pharmaceutical compositions, acetate buffer, and xanthan gum, along with specific herbal and pharmaceutical ingredients, to create a stable formulation that maintains microbiological and chemical quality, using advanced analytical methods to ensure potency and resolution of active ingredients.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Reliability

If herbal extracts are combined with pharmaceutical compositions, then synergistic therapeutic effects are achieved, but chemical stability and compatibility are compromised due to reactive chemical moieties causing degradation

Engineering Contradiction:

Improvetherapeutic efficacyVSAvoidchemical stability

Core Design Contradiction:

ReliabilityVSStability of the object's composition

Solution Approach 1:

The patent employs excipients such as solubilizers, complexing agents, and antioxidants as intermediary substances that mediate between herbal extracts and pharmaceuticals. These intermediaries prevent direct harmful reactions while maintaining therapeutic synergism, resolving the contradiction between efficacy and stability.

Inventive Principle:

Principle #24Intermediary (Mediator)

Solution Approach 2:

The invention creates a composite formulation system that integrates multiple components (herbal extracts, pharmaceuticals, excipients) into a unified stable matrix. This composite approach allows the system to maintain both the therapeutic benefits of ingredient combinations and the chemical stability required for shelf life.

Inventive Principle:

Principle #40Composite materials

2Ease of operation

If multiple herbal extracts and pharmaceuticals are combined in a single formulation, then consumer convenience and synergistic therapy are improved, but formulation complexity and manufacturing difficulty increase

Engineering Contradiction:

Improveconsumer convenienceVSAvoidformulation complexity

Core Design Contradiction:

Ease of operationVSDevice complexity

Solution Approach 1:

The patent merges multiple herbal extracts and pharmaceutical agents into a single integrated formulation, eliminating the need for consumers to separately manage multiple products. This combining approach achieves consumer convenience while the systematic formulation methodology manages the inherent complexity.

Inventive Principle:

Principle #5Merging (Combining)

Solution Approach 2:

The invention creates a universal formulation platform that can accommodate various herbal-pharmaceutical combinations for different therapeutic indications. This multi-functional approach simplifies the consumer experience while providing a systematic framework to handle formulation complexity through standardized development protocols.

Inventive Principle:

Principle #6Universality (Multi-functionality)

3Adaptability or versatility

If herbal extracts with diverse chemical moieties are used, then therapeutic versatility is enhanced, but compatibility and shelf life are reduced due to reactive components

Engineering Contradiction:

Improvetherapeutic versatilityVSAvoidshelf life

Core Design Contradiction:

Adaptability or versatilityVSDuration of action of stationary object

Solution Approach 1:

The patent utilizes parameter changes in the formulation environment, such as pH adjustment, oxidation-reduction potential control, and ionic strength modification, to stabilize reactive chemical moieties in herbal extracts. These parameter adjustments preserve therapeutic versatility while extending shelf life by preventing degradation reactions.

Inventive Principle:

Principle #35Parameter changes

Solution Approach 2:

The invention converts potentially harmful reactive chemical moieties in herbal extracts into beneficial components through strategic formulation. By using complexing agents and antioxidants, the reactive components that would normally cause degradation are transformed into stable, therapeutically active elements that contribute to both versatility and shelf life.

Inventive Principle:

Principle #22Blessing in disguise (Convert harm into benefit)

Data Source

PatentUS11351220B2Combined herbal and pharmaceutical composition and method

Publication Date: 2022.06.07 SYED UWAIS M

AI summary

An herbal combination composition can include, herbal extracts, including combinations of: Centella asiatica, licorice, Hyssopus officinalis, Zingiber officinale, Viola odorata, Ziziphus jujuba, Chamomile, and Ocimum tenuiflorum; pharmaceutical compositions, including combinations of: Brompheniramine Maleate, Pseudoephedrine, dextromethorphan, guaifenesin, acetaminophen, phenylephrine, diphenhydramine. The herbal combination composition can further include: polyethylene glycol; propylene glycol; poloxamer 407; ethylenediaminetetraacetic acid; methyl paraben; potassium sorbate; propyl paraben; xanthan gum; sodium citrate, citric acid; anhydrous citric acid; and purified acetate buffered water. Also disclosed is a method for manufacture of an herbal combination composition, including dissolving herbal extracts, adding poloxamer, adding pharmaceutical compositions, adding acetate buffer, adding xanthan gum gel, adding acetate buffer.