Herbal Composition Mobilizing Peripheral Blood Stem Cells
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Solution Overview
Problem
Current methods for mobilizing hematopoietic stem cells to peripheral blood, such as using G-CSF, come with risks like pain, osteoporosis, and increased cancer cell proliferation, limiting their effectiveness and safety for treatments like chemotherapy and radiotherapy.
Innovation Solution
A herbal medicinal composition comprising Cinnamomum Ramulus, Paeoniae Radix Rubra, Glycyrrhizae Radix, Zingiberis Rhizoma, Jujubae Fructus, Ginseng Radix, Deer Antler, Scutellariae Radix, and Astragali Radix is used to induce the production of peripheral blood stem cells by preparing a herbal medicinal extract through heating these herbs with water and adding Ginseng Radix and Deer Antler, which increases CD34(+) cells in peripheral blood lymphocytes.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Quantity of substance
If G-CSF is injected to stimulate HSCs mobilization, then the number of peripheral blood stem cells increases, but adverse effects such as bone pain, osteoporosis, and abnormal cell proliferation occur
Solution Approach 1:
The patent uses a herbal composition as an intermediary substance to achieve HSCs mobilization without directly injecting G-CSF. The herbal extract acts as a natural mediator that stimulates stem cell release through plant-based compounds, avoiding the harmful side effects of synthetic G-CSF while maintaining the therapeutic benefit of increased peripheral blood stem cells
Solution Approach 2:
The patent employs natural herbal materials that can be easily obtained and processed into extracts. These herbal components are biodegradable and metabolized naturally by the body, contrasting with the persistent and potentially harmful effects of G-CSF injection. The herbal composition provides a temporary, safe intervention that achieves mobilization without long-term adverse effects
2Productivity
If high dose radiotherapy or chemotherapy is used to treat malignant cancers, then the efficacy of cancer treatment improves, but the bone marrow is injured or inhibited
Solution Approach 1:
The patent applies the herbal composition before or during cancer treatment to pre-stimulate and mobilize HSCs to peripheral blood. This preliminary action creates a reservoir of stem cells that can be harvested and transplanted back to restore bone marrow function after high-dose chemotherapy or radiotherapy, thereby protecting hematopoietic function while maintaining cancer treatment efficacy
Solution Approach 2:
The herbal composition serves as a protective measure by预先 mobilizing stem cells to peripheral blood before bone marrow injury occurs. This creates a cushion or backup supply of stem cells that can be used for autograft transplantation, cushioning against the potential loss of hematopoietic function from high-dose cancer treatments
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The herbal composition effectively increases the number of CD34(+) cells in peripheral blood, promoting hematopoiesis without the adverse effects associated with G-CSF, thereby enhancing the safety and efficacy of stem cell mobilization for treatments.
Implementation Method 1
heating the herbs with water
Implementation Method 2
preparing a herbal medicinal extract through heating these herbs with water
Data Source
AI summary
A herbal medicinal composition and a herbal medicinal extract for inducing production of peripheral blood stem cells and a method for preparing the same. The herbal medicinal composition contains herbal medicinal herbs disclosed herein such as Cinnamomum Ramulus, Paeoniae (Ovatae) Radix Rubra, Glycyrrhizae Radix, Zingiberis Rhizoma, Jujubae Fructus, Anelicae Radix, and Astragali Radix.