Herbal Supplement for Bowel Disorder Relief
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Solution Overview
Problem
Current treatments for bowel disorders such as irritable bowel syndrome (IBS), functional constipation, and obesity are ineffective, with less than 14% of IBS patients satisfied with their treatment options.
Innovation Solution
A dietary supplement combining a polyphenol blend, specifically condensed tannins, with a spore-forming probiotic formulation, aimed at reducing bloating, constipation, diarrhea, dysbiosis, and weight gain by modulating the microbiome and intestinal health.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If conventional pharmaceutical treatments are used for bowel disorders, then treatment coverage is provided, but patient satisfaction remains low (less than 14% satisfied) and effectiveness is insufficient
Solution Approach 1:
The patent combines multiple herbal extracts (condensed tannins from quebracho, triterpenoid saponins from horse chestnut, and anti-spasmodic agents from peppermint) with spore-forming probiotics to create a composite formulation that addresses multiple bowel disorder mechanisms simultaneously, improving treatment effectiveness through synergistic action
Solution Approach 2:
The herbal composition is designed to perform multiple functions: reducing intestinal permeability, modulating LPS signaling, regulating cytokine production, improving microbiome balance, and disrupting bacterial biofilms, thereby providing comprehensive treatment for various bowel disorders with a single formulation
2Reliability
If the herbal supplement combines multiple active ingredients (polyphenols, saponins, anti-spasmodics, probiotics), then treatment efficacy is improved, but formulation complexity increases
Solution Approach 1:
The formulation is divided into distinct functional components: condensed tannins for intestinal permeability and biofilm disruption, triterpenoid saponins for anti-inflammatory effects, anti-spasmodic agents for symptom relief, and spore-forming probiotics for microbiome restoration, allowing each ingredient to be optimized independently while working synergistically
Solution Approach 2:
Spore-forming probiotics serve as intermediaries that colonize the gut and interact with the herbal compounds, enhancing their effects on the microbiome and intestinal environment, while the herbal extracts provide protective and modulatory functions that support probiotic activity
Data Source
AI summary
An herbal supplement for reducing bloating, dysbiosis, diarrhea, constipation and/or weight gain in a human subject is disclosed. The herbal supplement comprises an herbal composition comprising condensed tannin; an herbal composition comprising a triterpenoid saponin or an anti-spasmodic agent; and one or more probiotics in endospore form, wherein the supplement is formulated to reduce bloating, dysbiosis, diarrhea, constipation and/or weight gain in a human subject.