Herbicidal Amides Formula 1 Crop Selectivity
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Solution Overview
Problem
Current herbicidal compounds for controlling undesirable vegetation are either ineffective, costly, toxic, or environmentally harmful, and there is a need for new compounds that offer improved selectivity and safety for crops like rice, soybean, sugar beet, and others.
Innovation Solution
Development of a compound of Formula 1, including its stereoisomers, N-oxides, and salts, which are used in herbicidal compositions to effectively control unwanted vegetation by contacting the vegetation or its environment, offering a more effective, less toxic, and environmentally safer alternative.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If existing herbicidal compounds are used to control undesirable vegetation, then weed control effectiveness is achieved, but toxicity and environmental harm increase
Solution Approach 1:
The patent applies parameter changes by modifying the chemical structure of herbicidal compounds through specific substitution patterns on the phenyl ring (positions 2, 3, 4, 5, 6) and variations in the amide group configuration. These structural parameter changes result in compounds with improved selectivity and reduced toxicity while maintaining herbicidal activity, thereby resolving the contradiction between effectiveness and safety.
Solution Approach 2:
The patent segments the herbicidal compound structure into distinct functional regions: a core phenyl ring system, substituent groups at specific positions (R1-R6), and amide linkages. This segmentation allows for independent optimization of each region to achieve both high weed control effectiveness and reduced harm to crops and environment through systematic structure-activity relationship exploration.
2Reliability
If existing herbicidal compounds are used to control undesirable vegetation, then weed control is achieved, but crop safety decreases
Solution Approach 1:
The patent applies local quality by introducing specific substituent groups at defined positions on the phenyl ring structure. Each substituent (R1-R6) is strategically placed to provide localized functional properties that enhance selectivity between weed and crop sites. This local modification approach allows the compound to maintain herbicidal activity against weeds while being selectively safer for specific crops through localized structural differences.
3Object-affected harmful factors
If new herbicidal compounds are developed to improve safety and effectiveness, then crop safety and environmental safety improve, but compound complexity increases
Solution Approach 1:
The patent applies universality by designing a core phenyl-amide structural framework that serves multiple functions: maintaining herbicidal activity, providing crop selectivity, and enabling environmental safety. This universal core structure can accommodate various substituent patterns while preserving the fundamental herbicidal mechanism, thereby achieving improved safety without proportionally increasing complexity.
Data Source
AI summary
Disclosed are compounds of Formula 1, including all stereoisomers, N-oxides, and salts thereofwherein W, R1, J, Q1, R7, R8, Y, R9 and are as defined in the disclosure.Also disclosed are compositions containing the compounds of Formula 1 and methods for controlling undesired vegetation comprising contacting the undesired vegetation or its environment with an effective amount of a compound or a composition of the invention.