Herbicidal Amides Selective Weed Control

The patent applies local quality by introducing specific substituent groups at particular positions (R1-R10) in the amide structure. Different substituents are placed at specific locations to achieve selective herbicidal activity against weeds while maintaining compatibility with crop plants. For example, specific combinations of R1-R5 and R6-R10 create molecular regions that interact differently with weed and crop plant enzymes, achieving selective action.

The patent employs parameter changes by systematically varying the chemical parameters of the amide structure through different substituent combinations. The invention modifies physical-chemical parameters such as molecular weight, lipophilicity, and functional group arrangements to optimize herbicidal efficacy while reducing phytotoxicity to crops. This allows tuning of the compound's biological activity through structural parameter adjustment.

The patent uses local quality to create molecular structures with specific substituent patterns that enable high herbicidal effectiveness at low application rates. The carefully selected R1-R10 substituents create selective binding to weed enzymes (such as ALS inhibitors) that are present at lower concentrations in crops, allowing effective weed control without causing significant crop damage even at reduced dosages.

The patent applies copying by creating analogs and derivatives of existing amide structures through systematic substitution of R1-R10 groups. These copied structures retain the core herbicidal mechanism while modified substituents enhance selectivity and reduce crop phytotoxicity, allowing effective weed control at lower application rates compared to parent compounds.