Multifunctional Hernia Patch with Antibacterial and Hemostatic Properties
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Solution Overview
Problem
Existing composite meshes for intraperitoneal hernia surgery lack antibacterial and hemostatic properties, leading to post-operative complications such as infection, adhesion formation, and bleeding, despite their anti-adhesive properties.
Innovation Solution
Development of a composite mesh with anti-adhesive, antibacterial, and hemostatic properties using a PLGA blend system containing chitosan, applied via electrospinning on a polypropylene mesh, which accelerates tissue regeneration and prevents complications.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Object-affected harmful factors
If anti-adhesive membranes are used to prevent tissue adhesion, then adhesion formation is reduced, but antibacterial and hemostatic properties are lacking leading to post-operative complications
Solution Approach 1:
The patent applies composite materials by combining anti-adhesive membranes with antibacterial and hemostatic agents into a single integrated structure. The composite mesh includes a base mesh layer providing mechanical strength, an anti-adhesive layer preventing tissue adhesion, and embedded antibacterial/hemostatic components that release active substances. This multi-functional composite structure simultaneously addresses adhesion prevention while providing antibacterial and hemostatic protection, eliminating the need for separate materials and reducing post-operative complications.
2Strength
If synthetic mesh materials are used for hernia repair, then mechanical strength is provided, but tissue compatibility and biodegradability are compromised
Solution Approach 1:
The patent applies local quality by creating different functional zones within the mesh structure with distinct properties. The base mesh provides mechanical strength in load-bearing areas, while specific regions are coated or embedded with biodegradable polymers and bioactive substances that enhance tissue compatibility. The anti-adhesive layer is applied selectively on the intraperitoneal side, and antibacterial/hemostatic components are distributed in regions where they are most needed. This spatial differentiation of material properties allows the single mesh to simultaneously satisfy mechanical strength requirements and tissue compatibility demands.
3Ease of manufacture
If biodegradable materials are used for anti-adhesive membranes, then they are removed without medical intervention, but they lack antibacterial and hemostatic properties
Solution Approach 1:
The patent merges multiple functional characteristics into a single anti-adhesive membrane structure. The biodegradable base material provides self-removal capability, while antibacterial agents (such as silver nanoparticles or antibiotics) and hemostatic substances (such as thrombin or gelatin sponge) are integrated into the same membrane through embedding, coating, or composite fabrication. This merging of functions ensures that the membrane simultaneously prevents adhesion, fights infection, controls bleeding, and degrades autonomously, eliminating the need for separate interventions for each function.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The composite mesh effectively reduces post-operative complications by providing a non-toxic, antibacterial, and hemostatic barrier that promotes tissue regeneration and prevents adhesion formation, enhancing surgical outcomes.
Implementation Method 1
Electro-spinning methods are applied to design mesh composites. In this method, nanofibers with desired thickness and pore size can be practically obtained by changing the voltage, solution concentration, flow rate, the distance between needle tip and collector.
Implementation Method 2
chitosan, a natural polysaccharide, has been widely used in medicine due to its biocompatibility, biodegradability, non-toxicity, antibacterial, hemostatic and anti-inflammatory properties.
Implementation Method 3
chitosan, a natural polysaccharide, has been widely used in medicine due to its biocompatibility, biodegradability, non-toxicity, antibacterial, hemostatic and anti-inflammatory properties.
Data Source
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AI summary
This invention is associated with surgical implants with anti-adhesive, antibacterial and hemostatic properties to use in hernia repair. These implants comprise: a) Bilayer intraperitoneal mesh, which has certain thickness and porosity was prepared with combination of PP Mesh and blend system of biodegradable polyester-based polymers and polysaccharides coated on PP layer as nanofibers via electrospun technique, and, b) Double and/or triple-layer extraperitonal composite mesh, was prepared with blend systems of biodegradable polyester-based polymers and/or polysaccharides formed on PP/polyester woven material via different coating methods.