Hexamidine Diisethionate Solution in Alkanediol Mixtures
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Solution Overview
Problem
Current personal care products face challenges in achieving effective and safe preservation due to the limitations of existing antimicrobial agents, which can cause skin irritation, have undesirable side effects, or be ineffective, particularly in products for sensitive skin, facial care, intimate care, and children's products.
Innovation Solution
A stable liquid solution of hexamidine salts in a mixture of water and short-chain alkanediols with a C3 to C5 carbon chain, specifically hexamidine diisethionate, is developed, which exhibits synergistic antimicrobial and skin-moisturizing effects, enhancing preservative efficacy and skin compatibility.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If long-chain C6 to C10 alkanediols are used for preservation, then antimicrobial activity is improved, but skin irritation and greasy feeling increase
Solution Approach 1:
The patent changes the carbon chain length parameter of alkanediols from long-chain (C6-C10) to short-chain (C3-C5), specifically using 1,2-propanediol, 1,2-butanediol, or 1,2-pentanediol. This parameter change reduces skin irritation and greasy feeling while maintaining preservative efficacy when combined with hexamidine diisethionate
Solution Approach 2:
The patent creates a composite preservative system combining short-chain alkanediol with hexamidine diisethionate. The alkanediol serves as both solvent and preservative component, while hexamidine diisethionate provides enhanced antimicrobial activity. This composite approach achieves effective preservation with reduced skin irritation compared to using long-chain alkanediols alone
2Object-affected harmful factors
If short-chain C3 to C5 alkanediols are used, then skin compatibility is improved, but antimicrobial activity decreases
Solution Approach 1:
The patent merges short-chain alkanediol with hexamidine diisethionate in a combined preservative system. The short-chain alkanediol (providing skin compatibility) and hexamidine diisethionate (providing strong antimicrobial activity) work synergistically together, achieving both good skin tolerance and effective preservation
3Reliability
If hexamidine diisethionate is used as solid powder, then preservative efficacy is improved, but handling difficulty and dust irritation increase
Solution Approach 1:
The patent uses liquid 1,2-propanediol as a vehicle to dissolve hexamidine diisethionate, transforming it from a solid powder that generates irritating dust into a liquid solution that is easy to handle and apply. The liquid medium eliminates dust generation during handling while maintaining the preservative efficacy of hexamidine diisethionate
4Quantity of substance
If hexamidine salts are dissolved in water by heating, then solubility is improved, but processing complexity increases
Solution Approach 1:
The patent changes the solvent parameter from pure water to 1,2-propanediol-water mixtures. This parameter change allows hexamidine diisethionate to dissolve more easily in the 1,2-propanediol component, reducing or eliminating the need for heating and complex processing steps while achieving adequate solubility
Data Source
AI summary
The invention relates to a temperature-stable solution consisting of a) 0.1-10 wt.% of at least one hexamidine salt, b) 40-95 wt.% of an alkanediol with a C3 to C5 carbon chain and a cLogP of -0.2 to -1.1, c) 5-60 wt.% of water, and d) an additive or plurality of additives for adjusting the pH value of the solution to between 3.0 and 6.0 inclusive, wherein the total amount of components a) to d) is 100 wt.%.