HGF Protein Promotes Tendon-Bone Junction Regeneration
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Solution Overview
Problem
Current methods for promoting the regeneration of tendon-bone junction tissue or ligament-bone junction tissue after reconstructive surgery, such as ACL reconstructive surgery, are inefficient, leading to prolonged recovery times and complications like postoperative pain and muscle weakness due to the lack of effective adhesion between tendon or ligament grafts and bone.
Innovation Solution
The use of Hepatocyte Growth Factor (HGF) protein or its DNA encoding sequences, either alone or as partial peptides, to enhance the regeneration of tendon-bone junction tissue or ligament-bone junction tissue by promoting adhesion and fusion between bone and tendon or ligament grafts through topical application, potentially using vectors like HSV-1, Sendai virus, or adenovirus for delivery.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If conventional ACL reconstructive surgery using tendon grafts is performed, then the surgery allows early rehabilitation to start because the patellar tendon can function as a ligament when bones attach to each other, but the surgery has disadvantages such as postoperative pain and muscle weakness due to insufficient adhesion strength between tendon graft and bone
Solution Approach 1:
The patent introduces HGF protein as an intermediary substance applied to the bone surface in the bone tunnel before tendon graft implantation. This mediator promotes the regeneration of tendon-bone junction tissue, enhancing adhesion strength between the tendon graft and bone, thereby reducing postoperative complications while maintaining early rehabilitation benefits
2Reliability
If tendon graft is placed in bone tunnel to reconstruct ACL function, then the tendon graft performs substantially the same function as original ACL, but a long period of time is required before the tendon graft can function as a ligament due to insufficient tendon-bone junction tissue regeneration
Solution Approach 1:
The patent applies HGF protein to the bone surface in the bone tunnel before tendon graft implantation as a preliminary action. This pre-treatment accelerates the regeneration of tendon-bone junction tissue, enabling the tendon graft to function as a ligament in a shorter period while maintaining the reconstructed ACL function
Data Source
Figure 1~2B
AI summary
An object of the present invention is to provide a drug for promoting the regeneration of tendon-bone junction tissue or ligament-bone junction tissue. The present invention relates to a promoter for regeneration of tendon-bone junction tissue or ligament-bone junction tissue including the following (1) or (2) as an active ingredient: (1) the following (1-a), (1-b), or (1-c) (1-a) HGF protein, (1-b) a partial peptide of HGF protein, the peptide having an effect of promoting regeneration of tendon-bone junction tissue or ligament-bone junction tissue, (1-c) a salt of (1-a) or (1-b); (2) DNA including the following (2-a), (2-b), or (2-c), (2-a) DNA encoding HGF protein, (2-b) DNA encoding a partial peptide of HGF protein, the peptide having an effect of promoting regeneration of tendon-bone junction tissue or ligament-bone junction tissue, (2-c) DNA encoding a protein or a peptide, the protein or the peptide having an effect of promoting regeneration of tendon-bone junction tissue or ligament-bone junction tissue, and the DNA hybridizing with DNA comprising a base sequence complementary to (2-a) or (2-b) under a stringent condition.