High-Density Quercetin Granules for Better Dosage Flow
Find Innovative SolutionsGenerate Solutions
Solution Overview
Problem
Quercetin's poor flowability and low water solubility pose challenges in manufacturing dosage forms, leading to increased use of excipients, manufacturing inefficiencies, and reduced bioavailability.
Innovation Solution
A process involving roller compaction of quercetin to achieve high-density quercetin with improved flowability and compressibility, eliminating the need for additional excipients and enhancing manufacturing efficiency.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Quantity of substance
If quercetin is used in its native form, then the dosage form contains high quercetin strength, but the poor flowability requires high proportion of excipients (20-70 wt%)
Solution Approach 1:
The patent applies parameter changes by modifying the physical state and density of quercetin through granulation processes. The quercetin is transformed from a low-density powder into high-density granules with improved flow properties, allowing the same quercetin strength to be achieved with significantly reduced excipient content (from 20-70 wt% to much lower proportions).
Solution Approach 2:
The invention creates a composite structure by granulating quercetin with binding agents to form high-density granules. This composite approach improves the flowability and compressibility of quercetin while maintaining high active ingredient content, resolving the contradiction between quercetin strength and manufacturability.
2Device complexity
If quercetin is used in its native form, then the formulation is simple, but the poor flowability causes manufacturing inefficiencies and increased production times
Solution Approach 1:
The patent applies preliminary action by pre-granulating the quercetin into high-density form before the actual dosage form manufacturing. This pre-treatment of quercetin improves its flow and compression properties, enabling more efficient subsequent manufacturing steps and reducing overall production time without significantly complicating the formulation.
3Ease of manufacture
If quercetin is used in its native form, then no additional processing is required, but the low water solubility results in poor bioavailability
Solution Approach 1:
The patent applies parameter changes by modifying the physical form of quercetin through granulation, which alters its surface area, density, and porosity characteristics. These physical parameter changes improve the wetting and dissolution properties of quercetin, thereby enhancing its water solubility and bioavailability without requiring chemical modification or complex additional processing steps.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The high-density quercetin exhibits excellent flow properties, allowing for uniform dosage forms with reduced excipient use and improved solubility, thereby enhancing manufacturing efficiency and therapeutic efficacy.
Implementation Method 1
roller compaction of quercetin to achieve high-density quercetin
Data Source
AI summary
The invention relates to a process for preparing high-density quercetin of improved flowability comprising roller compaction of quercetin, wherein both the obtained high-density quercetin and the quercetin starting material have a purity of at least 95%. The invention also relates to the high-density quercetin obtainable with such process, to the use of high-density quercetin for preparing pharmaceutical dosage forms, to pharmaceutical dosage forms comprising high-density quercetin as active ingredient, and to their use in therapy and in cosmetics.