High Flow Rate Isolated Limb Infusion Catheter System

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Solution Overview

Problem

Isolated limb perfusion (ILP) is a complex, invasive, and costly procedure with significant complications, making it unsuitable for elderly patients and those with co-morbidities, while isolated limb infusion (ILI) is limited by low flow rates and difficulty in repeated treatments.

Innovation Solution

High flow rate isolated limb infusion (HF-ILI) method and system using percutaneously introduced catheters to infuse therapeutic agents at rates of 150 cc/min or higher, with optional tourniquet application to reduce systemic exposure and selective embolization to minimize collateral vessel flow, facilitating effective cancer treatment with reduced invasiveness and increased repeatability.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Quantity of substance

If isolated limb perfusion (ILP) is used to deliver high dose chemotherapeutic agents, then regional drug concentration is improved (up to 10-fold higher than systemic), but procedure complexity and invasiveness increase significantly

Engineering Contradiction:

Improveregional drug concentrationVSAvoidprocedure complexity

Core Design Contradiction:

Quantity of substanceVSDevice complexity

Solution Approach 1:

The patent changes the flow rate parameter from high flow (ILP) to low flow (ILI), achieving effective drug delivery at lower flows through prolonged infusion times. This parameter change simplifies the procedure while maintaining therapeutic efficacy

Inventive Principle:

Principle #35Parameter changes

Solution Approach 2:

The patent uses disposable percutaneous catheters instead of requiring permanent surgical implants or complex reusable equipment. The catheters are inserted percutaneously and removed after the infusion procedure, eliminating the need for complex surgical infrastructure

Inventive Principle:

Principle #27Cheap short-living objects (Disposable)

2Quantity of substance

If isolated limb perfusion (ILP) is used to deliver high dose chemotherapeutic agents, then regional drug concentration is improved, but systemic toxicity and complications increase

Engineering Contradiction:

Improveregional drug concentrationVSAvoidsystemic toxicity

Core Design Contradiction:

Quantity of substanceVSObject-affected harmful factors

Solution Approach 1:

The patent extracts the drug delivery function from the systemic circulation and confines it to the isolated limb circulation. By using percutaneous catheters inserted into limb vessels and inflating a tourniquet, the drug is delivered only to the target limb, preventing systemic toxicity while maintaining high regional concentrations

Inventive Principle:

Principle #2Taking out (Extraction)

3Device complexity

If isolated limb infusion (ILI) is used as a minimally invasive alternative, then procedure complexity is reduced, but flow rate is limited to low levels

Engineering Contradiction:

Improveprocedure complexityVSAvoidflow rate

Core Design Contradiction:

Device complexityVSProductivity

Solution Approach 1:

The patent uses a dynamic pump system that can adjust flow rates during the procedure. The pump is connected to the percutaneous catheters and can deliver controlled flow rates, allowing the system to transition from static low-flow ILI to dynamic flow-adjustable infusion, achieving both simplicity and adequate flow rates

Inventive Principle:

Principle #15Dynamics

4Reliability

If isolated limb perfusion (ILP) is used for cancer treatment, then treatment effectiveness is improved, but repeatability in the same extremity is reduced

Engineering Contradiction:

Improvetreatment effectivenessVSAvoidrepeatability

Core Design Contradiction:

ReliabilityVSAdaptability or versatility

Solution Approach 1:

The patent uses self-contained percutaneous catheters that can be inserted and removed without permanent implantation. The procedure does not require surgical incisions or permanent hardware in the limb, allowing the same extremity to be treated repeatedly. The system is self-service in that it uses the patient's own vasculature without requiring permanent modifications

Inventive Principle:

Principle #25Self-service

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

HF-ILI provides effective cancer treatment with higher flow rates and reduced systemic exposure, improving safety and accessibility for patients by minimizing complications and enabling more repeatable procedures compared to conventional ILI and ILP.

Implementation Method 1

percutaneuosly introducing a catheter into the vasculature of the subject

Methodology Applied

Scientific EffectPercutaneous introduction:

Implementation Method 2

applying a tourniquet proximal to the location where fluid is infused into the region from the catheter

Methodology Applied

Scientific EffectMechanical compression: Mechanical Force

Implementation Method 3

selective embolization to minimize collateral vessel flow

Methodology Applied

Scientific EffectVascular embolization:

Data Source

PatentUS20240299648A1High flow rate isolated infusion for regional treatment of cancer and medical conditions

Publication Date: 2024.09.12 H LEE MOFFITT CANCER CENTER & RESEARCH INSTITUTE INC

AI summary

The present application relates to high flow rate isolated regional treatment of cancer and proliferative disorders and conditions. For example, provided are methods, systems and devices for treating a cancer in a region of a subject using high flow rate isolated infusion.