High-NA Optical Fiber Probe for Non-Invasive Glucose Measurement
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Solution Overview
Problem
Current invasive glucose measurement methods are uncomfortable, costly, and discontinuous, and existing non-invasive methods are complex, expensive, or inefficient, particularly for patients with type 1 diabetes who require quick and precise glucose concentration monitoring.
Innovation Solution
A non-invasive glucose measurement device using a combination of scattering and transmission modules with high numerical aperture polymer optical fibers, semiconductor diodes, and a central control system, enabling quick and precise glucose concentration measurements without consumables, and allowing for wireless data transmission.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Measurement precision
If invasive measurement methods are used, then measurement precision is improved, but patient comfort and ease of operation deteriorate
Solution Approach 1:
The patent replaces the mechanical invasive puncture system with an optical measurement system. Instead of using needles to obtain blood samples, the invention uses light sources and detectors to measure glucose concentration through optical interactions with tissue, thereby eliminating physical intrusion while maintaining measurement capability
Solution Approach 2:
The patent introduces optical fibers as intermediaries between the measurement system and the patient's tissue. These optical fibers transmit light to and from the measurement site, enabling non-contact glucose concentration detection while maintaining measurement precision through the intermediary optical transmission medium
2Ease of operation
If traditional optical methods are used, then non-invasive measurement is achieved, but measurement precision and reliability deteriorate
Solution Approach 1:
The patent employs parameter changes by utilizing multiple wavelengths of light and varying temporal characteristics of light interaction with tissue. By analyzing changes in optical parameters (absorption, scattering) at different wavelengths and time points, the system achieves precise glucose concentration measurement while maintaining non-invasive operation
Solution Approach 2:
The patent implements feedback mechanisms where the measured optical signals are continuously processed and used to adjust and refine glucose concentration calculations. The system uses feedback from multiple measurement channels to compensate for variations in tissue properties and improve overall measurement precision and reliability
3Ease of operation
If Raman scattering methods are used, then non-invasive measurement is achieved, but device complexity and cost increase
Solution Approach 1:
The patent extracts and isolates the specific Raman scattering signal from glucose molecules by using optical filters and spectral analysis techniques. By separating the weak Raman signal from the much stronger background fluorescence and scattered light, the system achieves non-invasive measurement while managing device complexity through targeted signal extraction rather than requiring complex full-spectrum analysis
Solution Approach 2:
The patent uses optical fibers to create copies of the light path, allowing simultaneous measurement at multiple locations and wavelengths. The optical fiber bundle acts as a copying medium that distributes light to multiple sensing points and collects signals in parallel, reducing the complexity of individual measurement channels while maintaining comprehensive measurement capability
4Loss of information
If continuous monitoring is implemented, then information availability is improved, but measurement precision deteriorates due to body condition variations
Solution Approach 1:
The patent creates a universal measurement system that can operate under various body conditions by using multiple optical wavelengths and measurement modes. The system is designed to function across different tissue types, depths, and physiological states, providing continuous monitoring while maintaining precision through its multi-functional optical measurement approach that adapts to varying conditions
Solution Approach 2:
The patent implements dynamic measurement capabilities that adapt to changing body conditions in real-time. The system adjusts measurement parameters, wavelengths, and analysis methods based on detected variations in tissue properties, enabling continuous monitoring while compensating for body condition changes to maintain measurement precision throughout the monitoring period
Data Source
AI summary
The subject of the invention is a device for non-invasive blood glucose concentration measurement, comprising a central control system (4), a scattering module (1) and an electronic control system (2) of the scattering module (1) connected to it. The electronic control system (2) of the scattering module (1) is connected to the central control system (4). The scattering module (1) comprises a detection element (28) and a coherent radiation source (14) connected to the control system of the coherent radiation source (13). The device is characterized in that it further comprises a transmission module (7) and an electronic control system (8) of the transmission module (7) connected to it, connected to the central control system (4). The device further comprises a proximity sensor (12), connected to the central control system (4). The device comprises an optical fiber probe (11) comprising an emitting optical fiber (15) and a measuring optical fiber (18). The emitting optical fiber (15) is connected to a coherent radiation source (14). The measuring optical fiber (18) is connected to a detection element (28). The emitting optical fiber (15) and the measuring optical fiber (18) are parallel to each other within the optical fiber probe (11). The emitting optical fiber (15) and the measuring optical fiber (18) have a numerical aperture larger or equal to 0.5.