Highly Refined Cellulose for Cardiovascular Risk Reduction
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Solution Overview
Problem
Current dietary approaches to manage cardiovascular disease and diabetes are limited by the gastrointestinal side effects and low palatability of soluble fibers, which restrict their practical utility in reducing serum cholesterol and blood pressure effectively.
Innovation Solution
The use of highly refined cellulose (HRC), which is insoluble and indigestible, providing a substantial water retention capacity and viscosity similar to soluble fibers without causing adverse gastrointestinal effects, thereby effectively lowering risk factors for cardiovascular disease and diabetes.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If soluble fibers are used to lower serum cholesterol and blood pressure, then cardiovascular risk factors are reduced, but gastrointestinal side effects occur and palatability decreases
Solution Approach 1:
The patent applies parameter changes by modifying the physical and chemical properties of cellulose through highly refined processing. This transforms insoluble cellulose into a form with enhanced water retention capacity and viscosity, enabling it to function similarly to soluble fibers in lowering cholesterol and blood pressure without causing gastrointestinal side effects.
Solution Approach 2:
The patent creates a composite functional material by combining highly refined cellulose with specific physical characteristics (water retention capacity and viscosity) that were traditionally associated with soluble fibers. This composite approach allows the material to achieve the beneficial effects of soluble fibers while maintaining the advantages of insoluble fiber structure.
2Reliability
If soluble fibers are consumed to achieve hypolipidemic and hypotensive effects, then serum cholesterol and blood pressure are reduced, but gastrointestinal discomfort and low palatability limit practical utility
Solution Approach 1:
The patent modifies the physical parameters of cellulose to achieve high water retention capacity and viscosity, which are traditionally parameters of soluble fibers. This allows the use of insoluble fiber material to deliver soluble fiber-like health benefits without the associated gastrointestinal discomfort, thereby improving practical utility and compliance.
3Object-affected harmful factors
If insoluble fiber (cellulose) is used for dietary intervention, then gastrointestinal side effects are avoided, but lipid-lowering and blood pressure reduction effects are not achieved
Solution Approach 1:
The patent fundamentally changes the parameters of insoluble cellulose by enhancing its water retention capacity and viscosity through highly refined processing. This transformation enables the material to exhibit functional properties similar to soluble fibers, including the ability to lower serum lipids and blood pressure, while maintaining the advantage of avoiding gastrointestinal side effects.
Solution Approach 2:
The patent creates a composite functional profile by combining the base material of insoluble cellulose with enhanced water retention and viscosity characteristics. This composite approach allows the material to achieve lipid-lowering and blood pressure reduction effects traditionally associated with soluble fibers, while maintaining gastrointestinal tolerance.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
HRC effectively decreases serum lipids, blood pressure, and improves insulin sensitivity without the gastrointestinal side effects associated with soluble fibers, making it a viable nutritional and medical application for managing cardiovascular disease and diabetes.
Implementation Method 1
the HRC used in the present invention can also have an average pore diameter of about 39 Angstroms to about 49 Angstroms... HRC displays increased viscosity values for cellulose solutions having comparable amounts of cellulose material on a weight basis
Implementation Method 2
HRC does not dissolve in an aqueous solution, but rather forms a dispersion in solution, where discrete particles of HRC are in the aqueous solution... HRC displays increased viscosity values for cellulose solutions having comparable amounts of cellulose material on a weight basis
Data Source
AI summary
The present invention provides a method for using processed cellulose. Preferably, the processed cellulose is a highly refined cellulose (HRC). The HRC is useful in a number of medical and nutritional applications. These medical and nutritional applications can include, but are not limited to, administering effective amounts of the HRC for lowering values of risk factor measurements for such diseases as arteriosclerotic cardiovascular disease and diabetes. Treatment of other diseases and conditions with the HRC is also possible.