Enriched Hill Shaddock Oil Composition for IBD Inflammation Control
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Solution Overview
Problem
Current treatments for inflammatory bowel disease (IBD) often have poor prognosis and adverse effects, and there is a lack of research on the influence of fat components in medical formulas on inflammation, necessitating a dietary and nutritional intervention using enriched hill shaddock oil (HSO) to prevent or alleviate IBD.
Innovation Solution
A combination enriched with 30% to 50% by weight of branched chain fatty acid (BCFA) glycerides and 50% to 70% by weight of HSO, which includes specific fatty acid compositions and volatile flavor components, is developed to reduce intestinal tissue damage, promote repair, and regulate inflammatory reactions.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If conventional pharmacological treatments are used for IBD, then treatment effectiveness is achieved, but adverse effects occur and prognosis remains poor
Solution Approach 1:
The patent converts the harmful effects of conventional pharmacological treatments by introducing HSO-rich composition as an alternative that provides anti-inflammatory benefits without adverse effects. The composition uses natural fatty acid components (BCFA glycerides and HSO) to achieve treatment effectiveness while eliminating the harmful side effects associated with conventional drugs.
2Quantity of substance
If fat components are added to medical formulas for IBD, then nutritional support is provided, but influence on inflammation is unknown
Solution Approach 1:
The patent changes the compositional parameters of fat components by specifying precise proportions of BCFA glycerides (30-50% by weight) and HSO (50-70% by weight). This parameter optimization ensures both adequate nutritional support and reliable anti-inflammatory effects, transforming the unknown influence of fat components into a controlled, evidence-based formulation.
3Reliability
If BCFA glycerides are used to reduce inflammation, then anti-inflammatory effects are achieved, but unpleasant odors are generated
Solution Approach 1:
The patent introduces HSO as an intermediary substance that combines with BCFA glycerides in a synergistic formulation. HSO serves as a mediator that provides anti-inflammatory effects while its unique aroma masks the unpleasant odors associated with BCFA glycerides, creating a combined composition that achieves both therapeutic and sensory objectives.
Data Source
AI summary
A combination containing enriched hill shaddock oil (HSO) is provided to prevent or alleviate inflammatory bowel disease (IBD). The composition combination includes 30% to 50 wt % of branched chain fatty acid (BCFA) glycerides and 50% to 70 wt % of the oil-tea seed oil. The composition combination has significant anti-inflammatory effect on intestinal epithelial cells. Secretion of inflammatory factors is regulated to reduce the production of products of cellular inflammatory reactions. By adding HSO, intestinal tissue damage is alleviated, repair of the intestinal barrier is promoted, and the remission period of IBD is prolonged. The BCFA glycerides are formed by combining diacylglycerol with triacylglycerol and facilitate digestion, absorption, and metabolism, allowing relief of fat digestion and absorption disorders in patients suffering from IBD. In addition, the composition combination has enriched mono-unsaturated fatty acids, enabling the composition combination to be stable, facilitating regulation of human physiological functions and improving metabolism.