Percutaneous Hip Delivery System Preventing Carrier Overstuffing
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Solution Overview
Problem
Existing treatments for osteonecrosis, such as core decompression, face challenges with overstuffing or overpacking of growth factors like BMP on carriers, leading to bone resorption and potential further collapse of the hip due to excessively high concentrations.
Innovation Solution
A system for percutaneous delivery of growth factors to a pre-drilled bone space using an applicator and pusher device that prevents overstuffing, employing a carrier with compression-resistant materials like collagen sponge and biphasic ceramic granules to maintain a controlled concentration of growth factors.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If growth factors are packed into the pre-drilled bone space to stimulate bone formation, then bone regeneration is enhanced, but excessive concentration causes bone resorption and potential collapse
Solution Approach 1:
The applicator is designed with a predetermined length that corresponds to the depth of the pre-drilled bone space. This preliminary design ensures that when the applicator is inserted, it automatically stops at the correct position, preventing over-packing of the growth factor carrier before the bone formation process begins
Solution Approach 2:
The mechanical engagement between the pusher device and applicator creates a feedback mechanism through mechanical engagement features (such as tabs, slots, or threaded connections) that prevent the pusher from advancing beyond the applicator's distal end, providing real-time feedback to stop the packing process at the optimal point
2Strength
If a plug or screw is used to compact the bone-growth compound into the necrotic section, then structural strength is reinforced, but over-compaction creates excessively high growth factor concentration
Solution Approach 1:
The applicator is pre-designed with a specific length that matches the required insertion depth into the bone. This preliminary dimensional design ensures that the carrier is compacted to the exact extent needed for structural reinforcement without exceeding the safe concentration threshold for growth factors
Solution Approach 2:
The system changes the physical state and concentration parameters of the growth factor delivery by using a carrier of predetermined size and composition. The carrier's dimensions and material properties are specifically selected to provide the necessary structural support while releasing growth factors at controlled concentrations, transforming the delivery mechanism from manual packing to precision-engineered insertion
3Volume of stationary object
If the carrier is advanced further into the bone space to ensure complete filling, then bone voids are better filled, but overstuffing occurs leading to harmful effects
Solution Approach 1:
The applicator's length is predetermined during design to match the optimal insertion depth for filling bone voids. This preliminary dimensional specification ensures that the carrier fills the necessary volume without allowing the operator to inadvertently insert too much material that would cause overstuffing and subsequent bone resorption
Solution Approach 2:
The applicator acts as an intermediary device between the carrier and the bone space. It mediates the transfer of the carrier into the bone by providing a controlled pathway and stop mechanism, ensuring that the carrier is delivered to the correct depth and quantity without direct manual manipulation that could lead to overstuffing
Data Source
AI summary
Systems, methods, and carriers for percutaneous delivery of growth factors to treat osteonecrosis in the hip and other locations are disclosed. A rolled carrier comprising a biphasic ceramic rolled by a collagen sponge, and carrying a growth factor, are inserted via a delivery tube or cannula into a pre-formed hole in bone without overstuffing of the carrier or growth factor.