Histology Cassette Stack Connecting Strip Alignment

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Solution Overview

Problem

Manual loading and binding of histology processing cassettes for simultaneous processing are labor-intensive and prone to misalignment, as existing solutions require modifications to the cassette design for guiding means that can compromise the sample compartment or lead to dislodgment during use.

Innovation Solution

A stack of histology processing cassettes is designed with a connecting strip that threads through a single aperture in each cassette, allowing for easy alignment and registration without physical binding, using a deformable retaining part to maintain the stack's integrity and orientation, minimizing lateral movement and risk of dislodgment.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Ease of operation

If cassettes are physically bound together using weld seams or adhesive tapes, then transportation and loading are simplified, but the cassettes require additional processing steps and must be disconnected during use

Engineering Contradiction:
Improveloading processVSAvoidcassette structure
Core Design Contradiction:
Ease of operationVSDevice complexity

Solution Approach 1:

A connecting strip acts as an intermediary element that threads through apertures in multiple cassettes to bind them together in a stack. The connecting strip includes a retaining part that engages with the bottom cassette and a connecting part that links successive cassettes, enabling simple stacking without modifying the fundamental cassette structure.

Inventive Principle:
Principle #24Intermediary (Mediator)

2Ease of operation

If guide means are added to cassettes for band passage, then cassettes can be bound together, but the sample compartment space is reduced and dislodgment risk increases

Engineering Contradiction:
Improvecassette bindingVSAvoidsample compartment
Core Design Contradiction:
Ease of operationVSVolume of moving object

Solution Approach 1:

The connecting strip is a thin, flexible element that passes through apertures in the cassettes without requiring bulky guide means. The strip can be deformed during threading and then maintains the cassette stack through its flexibility, preserving the sample compartment volume while enabling secure binding.

Inventive Principle:
Principle #30Flexible shells and thin films

3Reliability

If multiple apertures are created in cassettes for connecting elements, then binding is more secure, but the risk of dislodgment during use increases

Engineering Contradiction:
Improvestack integrityVSAvoiddislodgment risk
Core Design Contradiction:
ReliabilityVSObject-affected harmful factors

Solution Approach 1:

The connecting strip is extracted from the cassette structure itself and implemented as a separate element that threads through apertures. The retaining part of the connecting strip engages with the bottom cassette to secure the stack, while the connecting part links successive cassettes, providing secure binding with minimal dislodgment risk.

Inventive Principle:
Principle #2Taking out (Extraction)

4Productivity

If standard size cassettes are used for majority of samples, then processing efficiency is maintained, but larger samples cannot be accommodated

Engineering Contradiction:
Improveprocessing throughputVSAvoidsample size accommodation
Core Design Contradiction:
ProductivityVSAdaptability or versatility

Solution Approach 1:

The connecting strip system provides a universal binding mechanism that works with cassettes of different sizes. The same connecting strip can bind standard size cassettes (28-32mm x 25-28mm x 5-6mm) as well as larger cassettes (50-55mm x 70-80mm x 5-16mm), enabling a single stack configuration to accommodate multiple sample sizes while maintaining processing efficiency.

Inventive Principle:
Principle #6Universality (Multi-functionality)

Data Source

PatentUS10288536B2Histology cassette stack
Publication Date: 2019.05.14 CELLPATH
  • US10288536B2 patent drawing
  • US10288536B2 patent drawing
  • US10288536B2 patent drawing

AI summary

A histology processing cassette stack having a plurality of cassettes for use in analyzing or processing biological samples is disclosed. The stack of cassettes are arranged in register and threaded on a connecting strip which passes through an aperture in a direction perpendicular to the plane of the cassette though a front wall of the cassette. The cassettes are held in fixed relation and may be transported and inserted en bloc into a magazine in a printing system by the connecting strip having a retaining part abutting the bottom cassette and able to bear the weight of the stack of cassettes when suspended. A printing system comprising a housing having a void for receiving a magazine loaded with the stack of cassettes is also disclosed.