Histone Modification Identification via Chromatin Structure Analysis
Find Innovative SolutionsGenerate Solutions
Solution Overview
Problem
Existing methods do not effectively acquire information about the activation and suppression of biological states in living organisms using epigenetic modifications.
Innovation Solution
A biological information processing method and device that acquire differences in chromatin structure and biological states over time, identify histone modifications causing these changes, and estimate corresponding modifications to activate or suppress specified biological states in target organisms.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Adaptability or versatility
If histone modification information is analyzed to identify correspondence with biological states, then the ability to activate or suppress specified biological states in target living bodies is improved, but the complexity of acquiring and processing chromatin structure data over time increases
Solution Approach 1:
The patent segments the complex task of histone modification analysis into distinct functional modules: a data acquisition unit that collects chromatin structure information at multiple time points, a difference calculation unit that computes temporal changes, and a correspondence identification unit that links modifications to biological states. This modular segmentation reduces processing complexity while maintaining the ability to identify effective histone modifications for activating or suppressing biological states in target living bodies.
Solution Approach 2:
The patent performs preliminary acquisition and analysis of chromatin structure data from source living bodies before applying the findings to target living bodies. By pre-identifying the correspondence between histone modifications and biological state changes through temporal data analysis, the system prepares a knowledge base that can be directly applied to activate or suppress desired biological states in targets, reducing the complexity of real-time intervention.
2Measurement precision
If multiple time points are used to analyze chromatin structure changes, then the precision of identifying causative histone modifications is improved, but the time required for data acquisition and analysis increases
Solution Approach 1:
The patent implements a self-service mechanism where the data acquisition unit automatically collects chromatin structure information at multiple predetermined time points without requiring manual intervention. The system autonomously tracks temporal changes, calculates differences, and identifies correspondence between histone modifications and biological state transitions. This automation reduces the effective time loss by eliminating manual data collection and processing steps while maintaining high precision through multi-temporal analysis.
Data Source
AI summary
A biological information processing method includes: acquiring differences between a chromatin structure of a living body and a biological state at a first point of time and a chromatin structure of the living body and a biological state at a second point of time after the first point of time respectively; identifying, based on the difference in the chromatin structure of the living body and the difference in the biological state, histone modification that causes alteration of the chromatin structure which alters the biological state; acquiring correspondence information indicating a correspondence between the identified histone modification and the biological state of the living body corresponding to the identified histone modification; and identifying, based on the correspondence information, the histone modification for activating or suppressing expression of a specified biological state in a target living body of a same type as the living body.