HMO Nutritional Composition for Longer Night Sleep in Infants
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Solution Overview
Problem
There is a need for nutritional compositions that can improve sleep quality and duration in infants and young children without inducing side effects, are easy to deliver, well accepted by parents and healthcare practitioners, and affordable.
Innovation Solution
A nutritional composition comprising human milk oligosaccharides such as 3′ sialyllactose (3-SL), lacto-N-tetraose (LNT), and core-HMOs, formulated in amounts ranging from 50 mg to 5000 mg/L, to enhance total night sleep duration and quality by increasing sleep time by at least 30 minutes and improving sleep quality through longer nights without frequent awakenings.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If conventional infant formulas are used, then basic nutritional needs are met, but sleep disturbances persist including short sleep duration and poor sleep quality
Solution Approach 1:
The patent extracts specific functional components (HMOs: 3-SL, LNT, core-HMOs) from human milk and incorporates them into infant formula to address sleep disturbances while maintaining basic nutritional functionality
Solution Approach 2:
The patent modifies the compositional parameters of infant formula by adding specific concentrations of HMOs (3-SL: 0.5-5 g/L, LNT: 0.5-5 g/L, core-HMOs: 0.5-5 g/L) to achieve improved sleep outcomes
2Duration of action of moving object
If HMOs are added to improve sleep quality, then sleep duration increases by at least 30 minutes, but formulation complexity increases
Solution Approach 1:
The patent segments the complex HMO profile into three specific target components (3-SL, LNT, core-HMOs) that can be individually controlled and added to achieve sleep benefits without requiring complete human milk replication
Solution Approach 2:
The patent creates a composite formula composition combining conventional infant formula nutrients with specific HMOs to achieve both basic nutrition and sleep improvement functions
Data Source
AI summary
The present invention relates to a nutritional composition comprising at least one human milk oligosaccharide comprising 3′ sialyllactose (3-SL), lacto-N-tetraose (LNT), core-HMOs and any combination thereof for improving improving total night sleep duration in a subject.