Hollow Amorphous Calcium Magnesium Phosphate for Dentin Tubule Mineralization
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Solution Overview
Problem
Existing amorphous calcium phosphate (ACP) particles are unstable and prone to crystallization, limiting their bioactive properties, and current treatments for dentin hypersensitivity do not effectively penetrate and mineralize dentin tubules, leading to inefficiencies and safety concerns in product formulation.
Innovation Solution
A composition of XRD amorphous calcium magnesium phosphate particles with a hollow core and a specific shell composition, stabilized by magnesium substitution, is produced through a continuous manufacturing process using controlled aqueous solutions, ensuring stability and ease of formulation into products like toothpaste, which facilitates deep penetration and efficient mineralization of dentin tubules.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If amorphous calcium phosphate particles are used to increase bioactivity and ion release, then the treatment efficacy for dentin hypersensitivity is improved, but the particles are unstable and prone to premature crystallization during storage and handling
Solution Approach 1:
Magnesium ions act as an intermediary stabilizer that prevents premature crystallization of amorphous calcium phosphate particles during storage and handling, while allowing controlled dissolution and ion release at the application site for effective dentin hypersensitivity treatment
Solution Approach 2:
The chemical composition parameters of the particles are modified by incorporating magnesium substitution, which changes the stability characteristics of the amorphous phase, enabling long-term storage stability while maintaining bioactive properties for ion release
2Stability of the object's composition
If traditional crystalline calcium phosphate particles are used for stability, then storage stability is improved, but the particles are less soluble and do not readily release calcium and phosphate ions
Solution Approach 1:
The crystalline structure is transformed into an amorphous phase through controlled precipitation, fundamentally changing the solubility and ion release parameters while magnesium substitution is introduced to compensate for the loss of structural stability, achieving both stability and high ion release capability
3Stability of the object's composition
If ACP particles are stabilized using milk derived casein phosphopeptide, then amorphous stability is improved, but the product contains potential allergens
Solution Approach 1:
Magnesium ions serve as an alternative intermediary stabilizer that replaces milk-derived casein phosphopeptide, eliminating allergen concerns while maintaining the amorphous stability of calcium phosphate particles through ionic interaction
Solution Approach 2:
The invention uses inorganic magnesium ions as a stable, non-allergenic stabilizing agent that does not require organic proteins, providing a safer and more universally applicable solution for dental products
4Stability of the object's composition
If in situ precipitated ACP is used by providing calcium and phosphate salts through dual-barrel delivery, then amorphous stability is improved, but the formulation complexity and device complexity increase
Solution Approach 1:
The amorphous calcium phosphate particles are pre-formed and stabilized with magnesium during manufacturing, eliminating the need for complex dual-barrel delivery systems that precipitate ACP in situ, thereby simplifying the formulation and application device while maintaining amorphous stability
5Ease of manufacture
If ACP particles are handled as fine powders through drying, milling and sieving, then the particles are easier to formulate, but safety concerns related to airborne particles increase
Solution Approach 1:
The particles are processed and formulated in liquid or slurry form using hydraulic methods, eliminating the need for drying, milling and sieving steps that generate airborne dust, thereby maintaining ease of manufacture while eliminating inhalation safety hazards
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The particles maintain amorphous stability for extended periods, efficiently penetrate and mineralize dentin tubules, providing enhanced treatment efficacy and reducing safety risks associated with traditional powder handling, while maintaining bioactive properties for effective dentin hypersensitivity relief.
Implementation Method 1
Amorphous calcium phosphate (ACP) is a metastable phase that lacks long range crystalline order... Stabilization of ACP can be achieved for example by Mg substitution
Implementation Method 2
The higher solubility of ACP makes it more bioactive as bioavailable calcium and phosphate ions are more readily released to the local environment
Implementation Method 3
CN107619031A discloses methods for preparing calcium phosphate and magnesium phosphate spherical particles... bringing the first and second aqueous solutions into contact with each other giving a third aqueous solution... wherein particles to form
Data Source
AI summary
The present invention relates to a particle composition comprising XRD amorphous calcium magnesium phosphate particles and a method for manufacturing such a composition. The XRD amorphous calcium magnesium phosphate particles are spherical particles with a hollow core. The particle-containing paste may be used in dental products such as toothpaste to treat dentin hypersensitivity by mineralizing and occluding exposed dentin tubules.