Hollow Fiber Membrane Antithrombotic Coating via CO2 Circulation
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Solution Overview
Problem
Hollow fiber membrane type artificial lungs face challenges with platelet adhesion and activation due to surface interactions, leading to potential thrombosis and plasma leakage, necessitating improved antithrombotic coatings to enhance patient safety and reduce burdens.
Innovation Solution
A method involving the use of a colloidal solution containing an antithrombotic high-molecular compound, such as polymethoxyethyl acrylate, is applied to the surfaces of hollow fiber membranes, with carbon dioxide circulation to increase the coating amount and enhance antithrombotic properties by aggregating colloidal particles and forming a thicker electric double layer.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If the hollow fiber membrane surface is coated with antithrombotic material to prevent platelet adhesion and activation, then the antithrombotic properties are improved, but the coating amount is insufficient and plasma leakage occurs
Solution Approach 1:
The patent changes the physical-chemical parameters of the colloidal solution by adjusting pH and adding salts to modify the electric double layer thickness and zeta potential. This causes colloidal particles to aggregate and deposit more extensively on the membrane surface, increasing the coating amount from insufficient levels to therapeutic levels (10-100 μg/cm²), thereby resolving the contradiction between achieving adequate coating quantity and maintaining antithrombotic quality
Solution Approach 2:
The patent uses composite colloidal particles consisting of hydrophilic polymer materials with antithrombotic properties (such as heparin, hirudin, or polyethylene glycol derivatives) dispersed in a colloidal solution. This composite structure allows the particles to maintain their antithrombotic functionality while achieving sufficient coating density on the membrane surface, simultaneously improving both coating amount and antithrombotic effectiveness
2Reliability
If the coating amount of antithrombotic material is increased to improve antithrombotic properties, then platelet adhesion and activation are suppressed, but the manufacturing complexity increases
Solution Approach 1:
The patent employs a self-assembling mechanism where colloidal particles automatically aggregate and deposit on the membrane surface through electrostatic interactions and electric double layer effects. The process utilizes the natural properties of the colloidal solution and membrane surface to achieve uniform coating without requiring complex application equipment or multi-step procedures, thereby increasing coating amount while minimizing manufacturing complexity
Solution Approach 2:
The patent introduces pH adjustment and salt addition as intermediary steps that mediate between the colloidal solution and membrane surface. These intermediaries control the electric double layer thickness and zeta potential to facilitate uniform particle deposition, achieving high coating amounts through simple, controllable chemical adjustments rather than complex physical application processes
Data Source
AI summary
A method is disclosed for producing an artificial lung including a plurality of porous hollow fiber membranes for gas exchange which have an outer surface, an inner surface forming a lumen, and an opening portion communicating the outer surface with the inner surface. The method includes bringing any of the outer surface and the inner surface into contact with a colloidal solution that contains an antithrombotic high-molecular compound to circulate carbon dioxide gas to a side of the other surface. According to the present disclosure, an artificial lung can be produced in which a coating amount of antithrombotic high-polymer material (an antithrombotic high-molecular compound) on a hollow fiber membrane is increased.