Hollow Microparticle Encapsulation for High Active-Agent Loading
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Solution Overview
Problem
Existing delivery systems for high potency active agents, such as biocides and agrochemicals, face challenges in achieving high loading capacities and efficient encapsulation, often resulting in diminished payload due to the use of trapping molecules.
Innovation Solution
The development of a composition comprising microparticles, specifically hollow microparticles like glucan or yeast cell wall particles, which allow for high loading of active agents ranging from 1% to 200% w/w, enabling efficient encapsulation of biologically active agents, agrochemicals, fragrances, and flavorings.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If trapping molecules are used to encapsulate active agents in delivery systems, then the delivery system provides controlled release and stability, but the loading capacity of the active agent is diminished
Solution Approach 1:
The patent removes the trapping molecule component from the encapsulation system, using hollow microparticles alone to contain the active agent. This extraction eliminates the conflict between trapping molecules providing stability and reducing loading capacity, allowing high loading without compromising delivery system integrity
Solution Approach 2:
The hollow microparticles provide a porous structure with internal cavities that can accommodate large quantities of active agent. The porous nature allows for high loading capacity while maintaining the structural integrity and controlled release properties of the delivery system
2Ease of manufacture
If conventional delivery systems are used for high potency active agents, then the system structure is simple and easy to manufacture, but the loading capacity is limited to low percentages
Solution Approach 1:
The patent employs hollow microparticles that function as nested containers, with the active agent nested within the hollow interior of the microparticles. This nesting approach maximizes the loading capacity by utilizing the internal volume of the microparticles, achieving loadings from 1% to 200% w/w while maintaining a simple two-component structure
Solution Approach 2:
The invention changes the physical parameter of the delivery system by using hollow microparticles with high internal volume-to-mass ratio. This parameter change enables dramatically increased loading capacity compared to conventional solid delivery systems, while the microparticles themselves remain simple in structure and easy to manufacture
Data Source
AI summary
There is described a composition comprising a microparticle component and a highly potent active agent encapsulated in the microparticle.