Honey and Extracellular Matrix Wound Composition
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Solution Overview
Problem
Current wound healing products either lack antibacterial properties or are cytotoxic, and existing antibacterial products can be ineffective in the presence of organic matter and may cause sensitization or allergies.
Innovation Solution
A composition combining honey with constituents of the extracellular matrix such as collagen, elastin, hyaluronic acid, and beta-glucans, which creates a moist environment and exhibits antibacterial activity without cytotoxicity, promoting healing and reducing bacterial load.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If silver-based dressings are used to provide antibacterial activity, then antibacterial properties are improved, but cytotoxicity increases causing cell death of cells involved in wound healing
Solution Approach 1:
The patent combines honey with extracellular matrix constituents (collagen, elastin, glycosaminoglycans) and beta-glucans to create a composite composition that provides both antibacterial activity and cell compatibility. This merging of multiple natural components achieves the desired antibacterial effect without the cytotoxicity of silver-based dressings.
Solution Approach 2:
The invention uses a composite material system consisting of honey combined with extracellular matrix components and beta-glucans. This composite approach allows the composition to exhibit both antibacterial properties and biocompatibility, resolving the contradiction between effective antibacterial activity and low cytotoxicity.
2Reliability
If iodine-based products are used to provide antibacterial activity, then antibacterial properties are improved, but cytotoxicity increases and antimicrobial activity decreases in the presence of organic matter
Solution Approach 1:
The patent merges honey with extracellular matrix constituents and beta-glucans to create a composition that maintains antibacterial activity even in the presence of organic matter such as pus, fibrin, or necrosis. This combination approach overcomes the limitation of iodine-based products whose antimicrobial activity decreases significantly when organic matter is present.
3Productivity
If conventional dressings are used to maintain a moist environment for healing, then healing promotion is improved, but antibacterial properties are lost
Solution Approach 1:
The patent creates a multi-functional composition that simultaneously provides both the moist environment necessary for healing promotion and inherent antibacterial activity. The combination of honey, extracellular matrix constituents, and beta-glucans enables the product to perform multiple functions that were previously requiring separate products.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The composition demonstrates a synergistic effect, enhancing wound healing by increasing skin cell proliferation and reducing bacterial proliferation, offering effective antibacterial activity without notable side effects, surpassing the performance of existing products.
Implementation Method 1
Some of these healing products work by maintaining a moist environment to promote healing
Implementation Method 2
The composition demonstrates a synergistic effect, enhancing wound healing by increasing skin cell proliferation
Implementation Method 3
honey has antibacterial and antifungal properties and that it reduces healing time, without infection or side effects
Data Source
AI summary
The subject matter of the invention is a healing and/or antibacterial composition comprising in particular honey, for use as a health product for topical application to the skin or the mucous membranes.