Honey Film Coating for Solid Dosage Forms
Find Innovative SolutionsGenerate Solutions
Solution Overview
Problem
Natural honey in film coatings for solid dosage forms can make them excessively sticky, leading to handling and packaging challenges, which detract from consumer experience and potentially affect the bioavailability of medicaments.
Innovation Solution
A film coating comprising 10% to 25% natural honey, combined with appropriate polymeric materials and sweeteners, to achieve a static coefficient of friction value less than 0.40, ensuring the dosage forms are not sticky while maintaining a strong honey flavor.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Ease of manufacture
If natural honey is included in film coating at levels sufficiently high to be perceived by consumers, then consumer acceptance and flavor perception are improved, but the solid dosage forms become excessively sticky and difficult to handle and package
Solution Approach 1:
The patent applies parameter changes by controlling the water content of the film coating to be between 2% and 10%, and the honey content to be between 0.1% and 5%. By optimizing these parameters, the coating maintains sufficient honey flavor perception while preventing excessive stickiness that would cause handling and packaging difficulties.
Solution Approach 2:
The patent uses composite materials by combining film coating materials with natural honey in specific proportions. The film coating serves as a matrix that contains the honey, providing both the desired flavor perception and the necessary anti-stick properties, creating a composite structure that balances flavor and handleability.
2Ease of manufacture
If natural honey is included in film coating, then consumer acceptance is improved, but the solid dosage forms may adhere to each other or packaging
Solution Approach 1:
The patent controls the water content parameter of the film coating to be between 2% and 10%, which optimizes the balance between honey flavor release and adhesion prevention. This parameter control ensures that the coating is not too dry (which would reduce flavor perception) and not too wet (which would increase adhesion to packaging).
Solution Approach 2:
The film coating acts as an intermediary layer between the solid dosage form core and the external environment (packaging and consumer). It mediates the interaction by providing a controlled interface that allows honey flavor perception while preventing direct contact between the sticky honey and the packaging materials.
3Ease of manufacture
If natural honey is included in film coating at high levels, then flavor perception is improved, but dissolution rate and bioavailability may be affected
Solution Approach 1:
The patent optimizes the honey content parameter to be between 0.1% and 5% and water content to be between 2% and 10%. These parameter ranges ensure that sufficient honey is present for consumer perception of flavor, while maintaining the dissolution characteristics necessary for reliable bioavailability of the medicament.
Solution Approach 2:
The patent applies local quality by concentrating the honey in the film coating layer rather than distributing it throughout the entire tablet. This allows the honey to provide flavor perception at the surface where consumers interact with the product, while the core medicament maintains its dissolution and bioavailability properties不受影响.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The solution allows for efficient packaging and handling of solid dosage forms without stickiness, while providing a perceived honey flavor that enhances consumer acceptance and maintaining the bioavailability of medicaments.
Implementation Method 1
the solid dosage form has a static coefficient of friction value of less than about 0.40
Data Source
Figure 1
AI summary
The invention is associated with ingestible film coated solid dosage forms comprising natural honey in the coating applied to such forms. The natural honey of the film coated solid dosage form is of sufficient level to be perceived by the user while avoiding sticking to each other or the packaging with which they are in contact and, or storage.