Hot-Water Eleutherococcus Extract pH Adjustment for Intestinal Function
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Solution Overview
Problem
Existing methods for producing Eleutherococcus extracts do not effectively enhance intestinal functions such as promoting uroguanylin or guanylin expression, intestinal peristalsis, or improving intestinal barrier function.
Innovation Solution
A method involving the use of sodium bicarbonate during the production of a hot water extract from the aerial parts of Eleutherococcus plants, specifically Eleutherococcus senticosus, to stimulate guanylate cyclase C receptor and increase intracellular CGMP concentration.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If conventional extraction methods are used for Eleutherococcus, then production process is simple, but intestinal function-promoting effect is insufficient
Solution Approach 1:
The patent changes the chemical parameter of the extraction solution by adding sodium bicarbonate to adjust pH, which enhances the extraction efficiency of active ingredients that promote uroguanylin and guanylin expression. This parameter modification resolves the contradiction by improving intestinal function-promoting effect while maintaining a relatively simple production process.
2Reliability
If extraction without sodium bicarbonate is used, then production cost is low, but uroguanylin or guanylin expression promotion is weak
Solution Approach 1:
By adjusting the pH parameter through sodium bicarbonate addition, the extraction process becomes more efficient at recovering active ingredients that promote uroguanylin and guanylin expression. This resolves the contradiction by achieving stronger expression promotion with only a modest increase in production cost due to the inexpensive nature of sodium bicarbonate.
3Reliability
If standard hot water extraction is used, then extraction time is short, but intestinal peristalsis promotion and inflammation suppression are insufficient
Solution Approach 1:
The addition of sodium bicarbonate modifies the chemical environment during extraction, enhancing the solubility and extraction efficiency of active ingredients responsible for intestinal peristalsis promotion and inflammation suppression. This allows achieving better therapeutic effects within a standard extraction time frame, resolving the contradiction without requiring extended extraction time.
Data Source
AI summary
A method for producing a hot water extract of an aboveground portion of a plant of the genus aralia comprising a step for adding sodium hydrogen carbonate. The extract so obtained is useful for promoting intestinal peristalsis, suppressing intestinal inflammation, improving intestinal barrier function, and/or promoting expression of uroguanylin or guanylin.