2-Hydroxypropyl-Beta-Cyclodextrin Obesity Treatment

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Solution Overview

Problem

Current obesity treatments and diabetes management methods are inadequate in effectively suppressing appetite, reducing body weight, and lowering blood sugar levels, often resulting in side effects and limited efficacy.

Innovation Solution

A pharmaceutical composition utilizing high water-soluble β-cyclodextrin derivatives, specifically 2-hydroxypropyl-β-cyclodextrin, which is administered to suppress appetite, decrease body fat, and lower blood sugar levels by inhibiting glycolysis and sugar absorption in the gastrointestinal tract.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Reliability

If conventional obesity treatments are used, then weight loss may be achieved, but side effects occur and efficacy is limited

Engineering Contradiction:

ImproveefficacyVSAvoidside effects

Core Design Contradiction:

ReliabilityVSObject-affected harmful factors

Solution Approach 1:

The patent uses β-cyclodextrin as an intermediary substance that binds to fatty acids in the intestine, forming inclusion complexes that prevent fat absorption. This mediator approach allows the treatment to reduce fat uptake without directly interfering with metabolic processes, thereby achieving weight loss efficacy while minimizing side effects compared to conventional obesity treatments

Inventive Principle:

Principle #24Intermediary (Mediator)

Solution Approach 2:

The patent modifies the chemical structure of cyclodextrin by introducing hydroxypropyl groups at specific positions (2-OH and 6-OH), changing the solubility parameter from poorly soluble to highly soluble in water. This parameter change enables the compound to be administered in aqueous solutions at therapeutic doses, improving reliability while maintaining safety profile

Inventive Principle:

Principle #35Parameter changes

2Quantity of substance

If high concentration of β-cyclodextrin is used to improve solubility, then water solubility increases, but crystalline structure stability decreases

Engineering Contradiction:

Improvewater solubilityVSAvoidcrystalline structure

Core Design Contradiction:

Quantity of substanceVSStability of the object's composition

Solution Approach 1:

The patent applies local quality modification by selectively substituting hydroxy groups at specific positions (2-OH and 6-OH) on the cyclodextrin ring structure with hydroxypropyl groups. This localized modification at specific sites enhances water solubility through increased hydrophilicity while preserving the overall cyclic structure and inclusion capability, thus maintaining compositional stability

Inventive Principle:

Principle #3Local quality

Solution Approach 2:

The patent creates a composite molecular structure combining the cyclic oligosaccharide backbone of β-cyclodextrin with hydroxypropyl side chains. This composite structure integrates the hydrophobic cavity of cyclodextrin for inclusion complex formation with the hydrophilic character of hydroxypropyl groups for water solubility, achieving both high solubility and structural stability

Inventive Principle:

Principle #40Composite materials

3Reliability

If existing diabetes management methods are used, then blood sugar control may be achieved, but effectiveness is limited

Engineering Contradiction:

ImproveeffectivenessVSAvoidblood sugar lowering efficiency

Core Design Contradiction:

ReliabilityVSProductivity

Solution Approach 1:

The patent converts the typically harmful effect of fat absorption into a beneficial outcome by using β-cyclodextrin to bind and sequester fatty acids in the intestine. This prevents fat from being absorbed and stored, and the bound fat-fatty acid complexes are excreted, thereby converting the presence of dietary fat into a mechanism that reduces overall caloric uptake and improves blood sugar control effectiveness

Inventive Principle:

Principle #22Blessing in disguise (Convert harm into benefit)

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

The composition effectively reduces body weight, decreases body fat, and lowers blood sugar levels without significant side effects, providing a more efficient treatment for obesity and diabetes management compared to existing methods.

Implementation Method 1

β-CD has a three-dimensional structure with a hydrophobic internal cavity and a hydrophilic external surface, and thus has a function of including various fat-soluble materials

Methodology Applied

Scientific EffectInclusion complex formation: Solvation

Implementation Method 2

decreasing blood sugar by suppressing glycolysis and sugar absorption in the gastrointestinal tract

Methodology Applied

Scientific EffectEnzyme inhibition: Enzyme

Data Source

PatentUS8975241B2Composition for treating and preventing obesity including high water-soluble 2-hydroxypropyl-betacyclodextrin as effective component

Publication Date: 2015.03.10 SONG HO BIOMED

AI summary

There is provided a composition for preventing and treating obesity including high water-soluble β-cyclodextrin derivatives as an effective component. Specifically, the composition including the high water-soluble β-cyclodextrin derivatives, especially, 2-hydroxypropyl-β-cyclodextrin (HP-β-CD, HPBCD) has effects on suppressing an increase in body weight induced by a high fat diet, suppressing appetite through decreasing an amount of dietary intake, decreasing body fat, decreasing liver weight, and significantly decreasing a sharp increase of blood sugar induced by intaking glucose and maltose on an empty stomach so that it can be useful for preventing and treating obesity, preventing and treating various diseases induced by obesity, and suppressing a sharp increase of blood sugar after dinner.