HPLC Valve Interconnection with Integrated Metering
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Solution Overview
Problem
Current High Performance Liquid Chromatography (HPLC) systems face challenges such as inability to simultaneously perform sample analysis and component cleaning, require multiple pumps, and lack flexibility in solvent selection during trapping and washing phases, leading to inefficiencies and increased complexity.
Innovation Solution
A system comprising two interconnected switching valves with an integrated metering device allows for simultaneous sample analysis, washing, and reloading of components, reducing the number of pumps needed and enabling flexible solvent selection, by using the metering device for both analytical and pre-compressing functions.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Adaptability or versatility
If multiple pumps are used to perform sample analysis and component washing separately, then the system can perform these functions, but the device complexity and number of components increase
Solution Approach 1:
The metering device is designed to perform multiple functions: it can deliver precise volumes for sample analysis and also perform component washing by connecting to different ports. This single device replaces what would traditionally require multiple separate pumps, reducing system complexity while maintaining versatility
Solution Approach 2:
The patent combines the sample analysis function and component washing function into a single integrated system using one metering device that can be configured for different operations by changing valve positions, merging previously separate functions into one unified component
2Productivity
If separate operations are performed sequentially (sample analysis then component washing), then system simplicity is maintained, but productivity and efficiency decrease
Solution Approach 1:
The system uses dynamically switchable valve configurations that can be changed during operation. The metering device can be repositioned between different ports to switch between sample analysis and component washing modes, allowing the system to adapt its configuration dynamically rather than requiring separate fixed systems
Solution Approach 2:
The system employs periodic switching between different operational modes. The metering device alternates between delivering samples for analysis and performing washing operations in a cyclic manner, enabling the system to perform multiple functions over time with a single integrated configuration
3Adaptability or versatility
If fixed solvent selection is used during trapping and washing phases, then system simplicity is maintained, but adaptability and flexibility decrease
Solution Approach 1:
The metering device is designed to handle different solvents and liquids universally. It can deliver mobile phase, wash solvents, and samples through the same device by simply changing the valve configuration, eliminating the need for separate delivery systems for each liquid type and providing flexibility in solvent selection
Data Source
AI summary
A system for component interconnection for use in liquid chromatography includes a first switching valve and a second switching valve. A first connecting line fluidly connects the first switching valve to the second switching valve. A second connecting line fluidly connects the first switching valve to the second switching valve. A metering device is located in the first connecting line.