Heparan Sulphate HS8 Stabilizes FGF2 for Skin Barrier Function
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Solution Overview
Problem
Current cosmetic and dermatological preparations using heparan sulfate do not effectively address anti-aging and moisturizing needs of the skin, particularly in enhancing skin hydration and barrier function.
Innovation Solution
Development of a heparan sulphate preparation, HS8, which binds to FGF2, providing anti-aging and moisturizing benefits by enhancing dermal fibroblast proliferation, down-regulating keratinocyte differentiation markers, and increasing the number of motile keratinocytes, formulated into cosmetic compositions for topical application.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If heparan sulfate is used in cosmetic preparations, then skin barrier function is improved, but anti-aging and moisturizing effects are insufficient
Solution Approach 1:
The patent changes the structural parameters of heparan sulfate by isolating specific chains with defined molecular weights (15-30 kDa) and sulfation patterns. This parameter optimization enhances both the barrier function and anti-aging effects, resolving the contradiction between reliability and productivity.
Solution Approach 2:
The patent creates a composite formulation by combining HS8 with FGF-2 (fibroblast growth factor). This composite material synergistically enhances skin barrier function while simultaneously providing potent anti-aging and moisturizing effects, addressing both aspects of the contradiction.
2Productivity
If FGF-2 is applied to enhance skin regeneration, then keratinocyte proliferation is improved, but stability and duration of action are limited
Solution Approach 1:
HS8 acts as an intermediary carrier that binds to FGF-2 and facilitates its stable delivery to target cells. This mediator approach protects FGF-2 from degradation while maintaining its biological activity, thereby extending its duration of action and enhancing keratinocyte proliferation.
Solution Approach 2:
The patent performs preliminary stabilization of FGF-2 by pre-complexing it with HS8 before application. This preliminary action protects the growth factor from degradation and ensures sustained release at the application site, extending its effective duration.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
HS8 effectively stabilizes FGF2, prolongs its action, and enhances skin hydration, improving skin appearance and barrier function, thereby providing anti-aging and moisturizing effects.
Implementation Method 1
HS8 has been found to bind FGF2... HS8 is capable of binding a peptide or polypeptide having the amino acid sequence of YCKNGGF
Data Source
AI summary
Affinity purification of fibroblast growth factor 2-binding heparan sulphate from porcine mucosa (HS8) is disclosed. Also disclosed is a process for the care of keratinous material(s), comprising the application or administration of HS8, or a composition comprising thereof, to keratinous material(s). The composition may be used to improve the condition of skin, such as smoothing the skin, restoring skin elasticity and firmness, or decreasing or preventing wrinkles, and may be formulated for topical or transdermal administration.