Human Milk Oligosaccharide Composition for Athlete Gut Microbiota Stability

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Solution Overview

Problem

Existing sports supplements, including probiotics and human milk oligosaccharides (HMOs), fail to effectively support intestinal health and improve sports performance and recovery in elite athletes, particularly due to disruptions in gastrointestinal microbiota and increased risk of infections from pathogens.

Innovation Solution

A composition comprising specific doses of HMOs, such as 2'-fucosyllactose, tailored for secretors and non-secretors, along with excipients like cranberry extract and antioxidants, to promote beneficial bacterial strains and enhance intestinal health, supporting immune function and athletic performance.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Duration of action of stationary object

If probiotic compositions are administered to improve sports performance, then recovery capacity is improved, but the influence on the immune system and risk of infections is limited

Engineering Contradiction:
Improverecovery capacityVSAvoidimmune system support and infection risk reduction
Core Design Contradiction:
Duration of action of stationary objectVSReliability

Solution Approach 1:

The patent combines prebiotic HMOs with probiotic compositions to create a synergistic effect. The prebiotic component selectively stimulates beneficial bacteria while the probiotic component introduces beneficial microorganisms, together providing comprehensive immune support and infection protection that neither component achieves alone.

Inventive Principle:
Principle #5Merging (Combining)

Solution Approach 2:

The invention uses a composite formulation containing both prebiotic HMOs and probiotic microorganisms. This composite approach allows the composition to simultaneously provide substrate for beneficial bacteria growth and introduce beneficial strains, addressing both recovery capacity and immune system reliability.

Inventive Principle:
Principle #40Composite materials

2Use of energy by moving object

If fructose-rich and artificial sweetener supplements are consumed to enhance performance, then energy availability is improved, but gastrointestinal microbiota regulation is disrupted and infection risk increases

Engineering Contradiction:
Improveenergy availabilityVSAvoidgastrointestinal microbiota disruption and infection risk
Core Design Contradiction:
Use of energy by moving objectVSObject-affected harmful factors

Solution Approach 1:

The patent converts the potential harm of supplement consumption by adding prebiotic HMOs that selectively nourish beneficial bacteria. These HMOs compete with pathogenic bacteria for resources, turning the supplement regimen into a beneficial intervention that protects against infections while maintaining energy availability.

Inventive Principle:
Principle #22Blessing in disguise (Convert harm into benefit)

Solution Approach 2:

The prebiotic HMOs act as intermediaries between the athlete's diet and the gastrointestinal microbiota. They selectively feed beneficial bacteria without directly introducing pathogens, mediating the interaction between supplement consumption and microbial balance to prevent infections.

Inventive Principle:
Principle #24Intermediary (Mediator)

3Productivity

If intensive training sessions are conducted to improve sports performance, then athletic capability is enhanced, but gastrointestinal microbiota is disrupted and recovery capacity is reduced

Engineering Contradiction:
Improveathletic capabilityVSAvoidgastrointestinal microbiota stability
Core Design Contradiction:
ProductivityVSStability of the object's composition

Solution Approach 1:

The patent applies preliminary action by administering prebiotic HMOs and probiotics before and during intensive training periods. This preparatory approach establishes a resilient microbiota community that can withstand the stresses of intensive training, preventing disruption before it occurs.

Inventive Principle:
Principle #10Preliminary action

Solution Approach 2:

The composition provides beforehand cushioning by introducing beneficial microorganisms and their substrates prior to training stress. This creates a protective buffer in the gastrointestinal tract that cushions against the disruptive effects of intensive training on microbiota stability.

Inventive Principle:
Principle #11Beforehand cushioning (Prior cushioning)

Data Source

PatentEP3930482B1Composition comprising human milk oligosaccharide for use in supporting and/or improving intestinal health
Publication Date: 2025.07.02 NUTRIBAM BV

AI summary

The present invention relates to a composition for use in supporting and/or improving intestinal health in athletes, comprising an effective dose of at least one human milk oligosaccharide (HMO) from the group of 2'-fucosyllactose (2'-FL), 3-fucosyl lactose (3-FL), lactodifucotetraose (DF-L), lacto-N-tetraose (LNT), lacto-N-neotetraose (LNnT), lacto-N-fucopentaose I (LNFP I), lacto-N-difucohexaose II (LNDFH II), lacto- N-neodifucohexaose II (LNnDFH II), para lacto-N-neohexaose (para-LNnH), lacto-N- neooctaose (LNnO), lacto-N-fucopentaose V (LNFP V), lacto-N-neofucopentaose V (LNnFP V), 3'-sialyl-3-fusoyl lactose (F-SL), LS-tetrasaccharide a (LSTa), 3'- sialyllactose (3'-SL), or combinations thereof.