Humanized CCR8 Animal Models for Accurate Drug Screening
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Solution Overview
Problem
Traditional drug development methods using in vitro screening and conventional animal models fail to accurately replicate human disease conditions due to the lack of a realistic body environment and differences between human and animal genetics, leading to high failure rates in drug development and clinical trials.
Innovation Solution
The development of genetically modified animals expressing human or chimeric CCR8, which are engineered to have a human or chimeric CCR8 gene sequence integrated into their genome, allowing for a more accurate representation of human immune system interactions and responses, enabling more effective drug screening and evaluation.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If conventional animal models are used for drug screening, then the complexity of the model is reduced, but the reliability of the results for predicting human disease response deteriorates
Solution Approach 1:
The patent applies local quality by selectively humanizing specific genes (CCR8) in the animal model rather than creating a fully humanized organism. This targeted approach introduces human-specific genetic characteristics at the precise locus needed for accurate drug screening, while maintaining the simplicity of conventional animal models for other physiological functions.
Solution Approach 2:
The patent uses an intermediary approach by creating a chimeric CCR8 receptor that combines human and animal genetic elements. This intermediate structure allows the animal model to respond to human therapeutics targeting human CCR8, bridging the gap between conventional animal models and fully human systems.
2Ease of operation
If in vitro screening approaches are used, then the ease of operation is improved, but the reliability of predicting in vivo drug effects deteriorates
Solution Approach 1:
The patent creates an intermediary system that combines the operational simplicity of in vitro screening with the physiological relevance of in vivo models. The genetically modified animals provide a living system that can be screened using standardized protocols, bridging the gap between cell culture simplicity and whole-organism physiological complexity.
Data Source
AI summary
Provided are genetically modified non-human animals that express a human or chimeric (e.g., humanized) CCR8, and methods of use thereof.