Hyaluronan Chloramide Iodide Composition for Stable Antimicrobial Wound Care
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Solution Overview
Problem
Current antimicrobial compositions with iodine having an oxidation degree higher than -1 face stability issues due to sublimation and require solvent presence, limiting their use in solid forms and causing skin irritation, while biocompatible oxidizing agents for in situ generation are not available.
Innovation Solution
A composition comprising iodide and biocompatible hyaluronan chloramide, where the hydrogen atoms in the amidic group are substituted with chlorine, generating iodine with an oxidation degree higher than -1 upon reaction with iodides in an aqueous environment, providing a stable and broad-spectrum antimicrobial effect.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If iodine with oxidation degree higher than -1 is used in antimicrobial compositions, then broad-spectrum antimicrobial effect is achieved, but stability is reduced due to sublimation and solvent requirements
Solution Approach 1:
The patent applies preliminary action by incorporating iodide salts and oxidizing agents into the composition in advance, but keeping them separated or in inactive forms until application. When the composition contacts the wound or moisture, the oxidizing agent converts iodide to active iodine species in situ, providing the antimicrobial effect only when needed. This prevents premature sublimation and maintains stability during storage and transport.
Solution Approach 2:
The patent uses iodide salts as intermediaries instead of直接使用 active iodine. The iodide salt serves as a stable precursor that can be stored without sublimation issues. Upon contact with moisture or oxidizing agents in the wound environment, the iodide converts to active iodine species (I2, I3-, IO3-) that provide the broad-spectrum antimicrobial effect. This intermediary approach resolves the contradiction between stability and antimicrobial activity.
2Stability of the object's composition
If solvent is added to maintain stability of iodine composition, then sublimation is prevented, but skin irritation occurs and biocompatibility is reduced
Solution Approach 1:
The patent extracts or removes the harmful solvent component from the composition while maintaining stability through alternative means. Instead of using organic solvents that cause skin irritation, the invention uses aqueous-based systems or solid-state formulations where iodide and oxidizing agents are stabilized without irritating solvents. The active iodine is generated in situ in a biocompatible environment, eliminating the skin irritation problem while maintaining both stability and antimicrobial efficacy.
3Ease of operation
If solid form is used for composition, then ease of application and storage is improved, but stability is reduced due to sublimation of iodine
Solution Approach 1:
The patent applies parameter changes by transforming the chemical state of iodine from molecular I2 (which sublimes) to iodide salts (which are stable solids). The composition is formulated as a solid containing iodide salts and oxidizing agents in inactive or stable forms. Upon application and contact with moisture, the parameters change: iodide converts to active iodine species that provide antimicrobial activity. This parameter transformation maintains both solid-form advantages and stability.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The composition ensures biocompatibility, biodegradability, and effective antimicrobial activity with controlled biodegradation, suitable for various forms and applications, including wound dressings and medical devices, without the limitations of sublimation or skin irritation.
Implementation Method 1
generates iodine having an oxidation degree higher than -1
Implementation Method 2
the aforesaid mixture generates iodine having an oxidation degree higher than -1
Data Source
Figure 1A
Figure 1B
AI summary
The invention relates to the preparation and use of various forms comprising iodides and a derivative of hyaluronic acid - a hyaluronan chloramide. These compositions, after being mixed in an aqueous medium, release compounds of iodine in the oxidation degree higher than -1, thus exhibiting a broad-spectrum antimicrobial activity. Thanks to the biocompatibility and stability these compositions are suitable for applications in the field of wound covers or for the preparation of wide range of implantable medical devices.