Hyaluronate Skin Penetration via Amphoteric Surfactant

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Solution Overview

Problem

Existing hyaluronic acid cosmetics struggle to penetrate the stratum corneum, leading to short-term moisturizing effects and the need for frequent application to improve skin wrinkles.

Innovation Solution

A hyaluronate skin-penetrating cosmetic comprising a hyaluronate and an amphoteric surfactant, which facilitates penetration without the need for complex nanoparticulation processes.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Duration of action of stationary object

If hyaluronic acid component is simply applied to the skin, then the moisturizing effect remains on the surface of the skin, but only a short-term moisturizing effect can be exerted

Engineering Contradiction:
Improveduration of moisturizing effectVSAvoidpenetration depth of hyaluronate
Core Design Contradiction:
Duration of action of stationary objectVSManufacturing precision

Solution Approach 1:

The patent changes the chemical parameters of the hyaluronate by converting it to a salt form (such as sodium hyaluronate, potassium hyaluronate, or ammonium hyaluronate) and controlling the molecular weight to 1,000,000 or less. This parameter transformation enables the hyaluronate to penetrate the stratum corneum effectively while maintaining moisturizing properties, thus extending the duration of action from short-term surface effect to long-term deep skin effect.

Inventive Principle:
Principle #35Parameter changes

2Manufacturing precision

If nanoparticulation of hyaluronic acid is performed by supporting on support material, then penetration capability is improved, but complicated steps such as ultracentrifugation are required for production

Engineering Contradiction:
Improvepenetration depth of hyaluronateVSAvoidcomplexity of production process
Core Design Contradiction:
Manufacturing precisionVSDevice complexity

Solution Approach 1:

The patent extracts and eliminates the complex nanoparticulation process and support materials from the formulation. Instead of using polylactic acid nanoparticles or zwitterionic compound complexes that require ultracentrifugation, the invention uses simple hyaluronate salts that can be directly applied to the skin, thereby removing the complicated production steps while maintaining effective skin penetration.

Inventive Principle:
Principle #2Taking out (Extraction)

Solution Approach 2:

The patent replaces complex, expensive nanoparticulation systems with simple, inexpensive hyaluronate salt formulations. These simple formulations achieve their purpose effectively without requiring sophisticated manufacturing equipment or multiple processing steps, making the production process more economical and accessible.

Inventive Principle:
Principle #27Cheap short-living objects (Disposable)

3Manufacturing precision

If composite formation of hyaluronic acid component is performed, then penetration capability is improved, but complicated steps are required for production

Engineering Contradiction:
Improvepenetration depth of hyaluronateVSAvoidease of production process
Core Design Contradiction:
Manufacturing precisionVSEase of manufacture

Solution Approach 1:

The patent removes the need for composite formation processes entirely. Instead of creating complexes with zwitterionic compounds or other materials that require sophisticated manufacturing, the invention uses pure hyaluronate salts that can be manufactured through simple, straightforward processes, greatly improving ease of manufacture while maintaining penetration effectiveness.

Inventive Principle:
Principle #2Taking out (Extraction)

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

The cosmetic allows for deeper penetration of hyaluronate into the skin, providing sustained moisturizing effects and improving skin health without the need for frequent application.

Implementation Method 1

a hyaluronate skin-penetrating cosmetic, comprising a hyaluronate and an amphoteric surfactant

Methodology Applied
Scientific EffectSurfactant action: Surfactant

Data Source

PatentUS20250032392A1Hyaluronate skin-penetrating cosmetic
Publication Date: 2025.01.30 SHISEIDO CO LTD
  • US20250032392A1 patent drawing
  • US20250032392A1 patent drawing
  • US20250032392A1 patent drawing

AI summary

To provide a hyaluronate skin-penetrating cosmetic that allows a hyaluronate to penetrate into the skin without a complicated step such as composite formation of a hyaluronate.A hyaluronate skin-penetrating cosmetic of the present disclosure contains a hyaluronate and an amphoteric surfactant.