Hyaluronate Glucomannan Microspheres for Skin Hydration

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Solution Overview

Problem

Existing cosmetic and dermatological solutions for reducing wrinkles are either invasive, expensive, or have secondary effects like infections and allergies, and they do not effectively fill out the skin mechanically without penetrating the dermis.

Innovation Solution

Development of microspheres composed of cross-linked hyaluronate and glucomannan polymers, which are applied topically, act mechanically on the epidermis, and are easy to manufacture and stable, using interfacial cross-linking to form ester bonds for enhanced water retention and skin hydration.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Object-affected harmful factors

If existing cosmetic solutions are used to reduce wrinkles, then wrinkle visibility is reduced, but they cause harmful effects like infections and allergies

Engineering Contradiction:

Improveinfections and allergiesVSAvoidwrinkle reduction effectiveness

Core Design Contradiction:

Object-affected harmful factorsVSReliability

Solution Approach 1:

The patent uses biodegradable polysaccharide polymers (hyaluronate and glucomannan) that temporarily fill wrinkles and then naturally degrade without causing long-term harmful effects. These polymers are designed to be short-lived in the skin, eliminating persistent infections and allergies while providing effective temporary wrinkle reduction.

Inventive Principle:

Principle #27Cheap short-living objects (Disposable)

Solution Approach 2:

The invention combines two different polysaccharide polymers (hyaluronate and glucomannan) into a composite material that leverages the benefits of both components. Hyaluronate provides water retention and skin hydration, while glucomannan enhances structural support and biodegradability, creating a material that is both effective and safe.

Inventive Principle:

Principle #40Composite materials

2Strength

If high molecular weight sodium hyaluronate microspheres are used, then mechanical filling effect is achieved, but water retention and hydration are insufficient

Engineering Contradiction:

Improvemechanical filling effectVSAvoidwater retention capacity

Core Design Contradiction:

StrengthVSQuantity of substance

Solution Approach 1:

The patent creates a composite polymer system where hyaluronate (known for superior water retention) is combined with glucomannan (providing structural strength). This composite structure allows the microspheres to maintain strong mechanical filling effects while simultaneously improving water retention and skin hydration capabilities beyond what high molecular weight sodium hyaluronate alone can achieve.

Inventive Principle:

Principle #40Composite materials

Solution Approach 2:

The invention modifies the molecular weight parameters of the polysaccharide polymers used. Instead of using only high molecular weight sodium hyaluronate, the patent employs polysaccharide polymers with optimized molecular weight ranges that balance mechanical strength for filling with sufficient water retention capacity, achieving both requirements simultaneously.

Inventive Principle:

Principle #35Parameter changes

3Stability of the object's composition

If cross-linking agents are used to form polymer networks, then structural stability is improved, but manufacturing complexity increases

Engineering Contradiction:

Improvepolymer network stabilityVSAvoidmicrosphere production simplicity

Core Design Contradiction:

Stability of the object's compositionVSEase of manufacture

Solution Approach 1:

The patent employs self-cross-linking mechanisms where the polysaccharide polymers (hyaluronate and glucomannan) naturally form cross-linked networks through their inherent functional groups without requiring complex external cross-linking agents. This self-organizing property simplifies manufacturing while maintaining structural stability of the polymer network.

Inventive Principle:

Principle #25Self-service

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

The microspheres demonstrate improved water capture and retention, providing effective mechanical filling and hydration, reducing wrinkle visibility, and are well-tolerated by the skin with long-lasting action.

Implementation Method 1

using interfacial cross-linking to form ester bonds for enhanced water retention and skin hydration

Methodology Applied

Scientific EffectEster bond formation: Chemical Bonding

Implementation Method 2

demonstrate improved water capture and retention, providing effective mechanical filling and hydration

Methodology Applied

Scientific EffectWater retention: Absorption (physical)

Data Source

PatentUS11439579B2Polymer of hyaluronate and of glucomannan

Publication Date: 2022.09.13 BASF BEAUTY CARE SOLUTIONS FRANCE SAS

AI summary

The present invention concerns a sphere, characterized in that it comprises at least one polymer of hyaluronate and glucomannan. It also concerns a polymer of hyaluronate and glucomannan characterized in that each bond between a hyaluronate group and a glucomannan group is an ester bond. In addition, it concerns their production process and their use, in particular as a filling or hydration agent.